Expression of the gene encoding HLA class II antigen-associated invariant chain was studied in several types of fresh human malignant lymphoma by Northern blot analysis or slot-blot analysis. The invariant chain mRNA levels decreased with the stage of B-lymphocyte differentiation to plasma cells such as in immunoblastic lymphoma (IBL) or multiple myeloma (MM). The invariant chain gene (In-gene) was expressed in diffuse large cell lymphoma (DLCL), while its expression was hardly detected in IBL. It is suggested that the difference in In-gene expression between DLCL and IBL could be useful in distinguishing these two morphologically similar diseases.

HLA class II antigen associated invariant chain gene expression in malignant lymphoma / H., Gondo; Narni, Franco; M., Lee; M. B., Blick; F., Cabanillas; G. F., Saunders. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - STAMPA. - 67:(1987), pp. 413-417.

HLA class II antigen associated invariant chain gene expression in malignant lymphoma.

NARNI, Franco;
1987

Abstract

Expression of the gene encoding HLA class II antigen-associated invariant chain was studied in several types of fresh human malignant lymphoma by Northern blot analysis or slot-blot analysis. The invariant chain mRNA levels decreased with the stage of B-lymphocyte differentiation to plasma cells such as in immunoblastic lymphoma (IBL) or multiple myeloma (MM). The invariant chain gene (In-gene) was expressed in diffuse large cell lymphoma (DLCL), while its expression was hardly detected in IBL. It is suggested that the difference in In-gene expression between DLCL and IBL could be useful in distinguishing these two morphologically similar diseases.
1987
67
413
417
HLA class II antigen associated invariant chain gene expression in malignant lymphoma / H., Gondo; Narni, Franco; M., Lee; M. B., Blick; F., Cabanillas; G. F., Saunders. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - STAMPA. - 67:(1987), pp. 413-417.
H., Gondo; Narni, Franco; M., Lee; M. B., Blick; F., Cabanillas; G. F., Saunders
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/456128
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