The primary structures of a cDNA and the genomic DNA of a gene selectively expressed in chronic lymphocytic leukemia were determined. A computer search of the nucleotide sequence data bank identified this gene as the invariant y-chain associated with class II histocompatibility antigens. The invariant y-chain genomicsequence spans about 11 kilobases, with eight exons and seven introns. Three of the introns contain members of the Alu repeat family. A putative cap site and promoter sequence were identified at the 5' end of the gene. One or two copies of the gene ispresent in each haploid genome, and no evidence for amplification or polymorphism was obtained

Structure of the human gene encoding the invariant gamma chain of class II histocompatibility antigens / Kudo, J.; Chao, L. Y.; Narni, Franco; Saunders, G. F.. - In: NUCLEIC ACIDS RESEARCH. - ISSN 0305-1048. - STAMPA. - 13:(1985), pp. 8827-8841.

Structure of the human gene encoding the invariant gamma chain of class II histocompatibility antigens.

NARNI, Franco;
1985

Abstract

The primary structures of a cDNA and the genomic DNA of a gene selectively expressed in chronic lymphocytic leukemia were determined. A computer search of the nucleotide sequence data bank identified this gene as the invariant y-chain associated with class II histocompatibility antigens. The invariant y-chain genomicsequence spans about 11 kilobases, with eight exons and seven introns. Three of the introns contain members of the Alu repeat family. A putative cap site and promoter sequence were identified at the 5' end of the gene. One or two copies of the gene ispresent in each haploid genome, and no evidence for amplification or polymorphism was obtained
1985
13
8827
8841
Structure of the human gene encoding the invariant gamma chain of class II histocompatibility antigens / Kudo, J.; Chao, L. Y.; Narni, Franco; Saunders, G. F.. - In: NUCLEIC ACIDS RESEARCH. - ISSN 0305-1048. - STAMPA. - 13:(1985), pp. 8827-8841.
Kudo, J.; Chao, L. Y.; Narni, Franco; Saunders, G. F.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/456125
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