Comparison of protein kinase activity in normal and regenerating rat liver nuclei indicates that exogenous histone H1 is hyperphosphorylated in 22-h regenerating nuclei. The protein kinase involved is not sensitive to protein kinase A inhibitor, is inhibited by staurosporine and by an anti-PKC polyclonal antibody, utilizes only ATP, and also phosphorylates the C-terminal fragment of histone H1. These data suggest that protein kinase C is responsible for the observed effects, in agreement with the presence of this enzyme in normal and regenerating nuclei demonstrated by immunoblotting.IF 3.949

Nuclear protein kinases in rat liver: evidence for increased Histone H1 phosphorylating activity during liver regeneration / A. M., Martelli; C., Carini; Marmiroli, Sandra; M., Mazzoni; P. J., Barker; R. S., Gilmour; S., Capitani. - In: EXPERIMENTAL CELL RESEARCH. - ISSN 0014-4827. - STAMPA. - 195:(1991), pp. 255-262.

Nuclear protein kinases in rat liver: evidence for increased Histone H1 phosphorylating activity during liver regeneration.

MARMIROLI, Sandra;
1991

Abstract

Comparison of protein kinase activity in normal and regenerating rat liver nuclei indicates that exogenous histone H1 is hyperphosphorylated in 22-h regenerating nuclei. The protein kinase involved is not sensitive to protein kinase A inhibitor, is inhibited by staurosporine and by an anti-PKC polyclonal antibody, utilizes only ATP, and also phosphorylates the C-terminal fragment of histone H1. These data suggest that protein kinase C is responsible for the observed effects, in agreement with the presence of this enzyme in normal and regenerating nuclei demonstrated by immunoblotting.IF 3.949
1991
195
255
262
Nuclear protein kinases in rat liver: evidence for increased Histone H1 phosphorylating activity during liver regeneration / A. M., Martelli; C., Carini; Marmiroli, Sandra; M., Mazzoni; P. J., Barker; R. S., Gilmour; S., Capitani. - In: EXPERIMENTAL CELL RESEARCH. - ISSN 0014-4827. - STAMPA. - 195:(1991), pp. 255-262.
A. M., Martelli; C., Carini; Marmiroli, Sandra; M., Mazzoni; P. J., Barker; R. S., Gilmour; S., Capitani
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/455588
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