During the past decade, a small number of families of secreted proteins have emerged as key regulators of many of the important inductive interactions that control the development of animal embryos. Members of these families - the fibroblast growth factors (FGFs), transforming growth factor-βs (TGF-βs), Wnts, and Hedgehogs (Hhs) - have been highly conserved during evolution and in some cases have remarkably similar roles in the development of species from different phyla.
The Smoothened gene and Hedgehog signal transduction in Drosophila and vertebrate development / Quirk, J.; VAN DEN HEUVEL, M.; Henrique, D.; Marigo, Valeria; Jones, T. A.; Tabin, C.; Ingham, P. W.. - In: COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY. - ISSN 0091-7451. - STAMPA. - LXII:(1997), pp. 217-226.
The Smoothened gene and Hedgehog signal transduction in Drosophila and vertebrate development.
MARIGO, Valeria;
1997
Abstract
During the past decade, a small number of families of secreted proteins have emerged as key regulators of many of the important inductive interactions that control the development of animal embryos. Members of these families - the fibroblast growth factors (FGFs), transforming growth factor-βs (TGF-βs), Wnts, and Hedgehogs (Hhs) - have been highly conserved during evolution and in some cases have remarkably similar roles in the development of species from different phyla.
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