Persistent organic pollutants (POPs) such as polychlorinated dibenzo-p-dioxins/furans, polychlorinated biphenyls (PCBs) and organochlorine pesticides can cause a series of adverse effects on e.g. reproduction in animals and humans, many of which involve the aryl hydrocarbon receptor (AhR). The aim of the present study was to compare the integrated serum level of AhR mediated activity among European and Inuit populations, and evaluate whether the activity was associated to the selected POP markers, 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE).
Dioxin-like activities in serum across European and Inuit populations / Long, M; Andersen, Bs; Lindh, Ch; Hagmar, L; Giwercman, A; Manicardi, Gian Carlo; Bizzaro, D; Span, M; Toft, G; Pedersen, Hs; Zvyezday, V; Bonde, Jp; BONEFELD JORGENSEN, Ec. - In: ENVIRONMENTAL HEALTH. - ISSN 1476-069X. - ELETTRONICO. - 5:(2006), pp. 1-14. [10.1186/1476-069X-5-14]
Dioxin-like activities in serum across European and Inuit populations.
MANICARDI, Gian Carlo;
2006
Abstract
Persistent organic pollutants (POPs) such as polychlorinated dibenzo-p-dioxins/furans, polychlorinated biphenyls (PCBs) and organochlorine pesticides can cause a series of adverse effects on e.g. reproduction in animals and humans, many of which involve the aryl hydrocarbon receptor (AhR). The aim of the present study was to compare the integrated serum level of AhR mediated activity among European and Inuit populations, and evaluate whether the activity was associated to the selected POP markers, 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE).
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