We read with interest the recent article by Ray and coworkers reporting that human parvovirus B19 infection can induce in vitro invasive properties in normal human synovial fibroblasts . Their study further supports previous observations suggesting that B19 infection could be involved in the pathogenesis of rheumatoid arthritis and other rheumatic disorders, including systemic sclerosis (SSc) . SSc is a connective tissue disease of unknown etiology; its pathogenesis involves overproduction of collagen by altered fibroblasts and alterations of the microvasculature and immune system . Numerous genetic, environmental, and infectious agents have been proposed as possible etiologic factors
Parvovirus B19 infection of cultured skin fibroblasts from systemic sclerosis patients: comment on the article by Ray et al / Ferri, Clodoveo; Giuggioli, D.; Sebastiani, Marco; Panfilo, S.; Abatangelo, G.; Zakrzewska, K; Azzi, A.. - In: ARTHRITIS AND RHEUMATISM. - ISSN 0004-3591. - STAMPA. - 46:8(2002), pp. 2262-2263. [10.1002/art.10346]
Parvovirus B19 infection of cultured skin fibroblasts from systemic sclerosis patients: comment on the article by Ray et al
FERRI, Clodoveo;Giuggioli D.;SEBASTIANI, Marco;
2002
Abstract
We read with interest the recent article by Ray and coworkers reporting that human parvovirus B19 infection can induce in vitro invasive properties in normal human synovial fibroblasts . Their study further supports previous observations suggesting that B19 infection could be involved in the pathogenesis of rheumatoid arthritis and other rheumatic disorders, including systemic sclerosis (SSc) . SSc is a connective tissue disease of unknown etiology; its pathogenesis involves overproduction of collagen by altered fibroblasts and alterations of the microvasculature and immune system . Numerous genetic, environmental, and infectious agents have been proposed as possible etiologic factorsPubblicazioni consigliate
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