To evaluate the autonomic nervous control of the heart in patients with systemic sclerosis (SSc), spontaneous heart rate variability was investigated by means of time-domain and spectrum analysis of 24 h ECG ambulatory recordings in 30 SSc patients (four males, aged 45.2 +/- 9 yr, mean +/- S.D., range 27-60) and 30 age-matched healthy subjects. A significantly higher heart rate (P < 0.01) and lower circadian and spectral indices of heart rate variability (P < 0.01) were observed in SSc patients, compared with controls. A predictive value of age (P = 0.002), tachycardia (P = 0.002), circadian heart rate variability (P = 0.0025) and spectral power values (P = 0.005) for patient mortality was found. Moreover, the relative risk of death was higher (P = 0.05) in older subjects with circulating anti-Scl70. These abnormalities, detectable by a feasible, non-invasive diagnostic approach, indicate the presence of autonomic cardiac neuropathy in SSc patients

Autonomic dysfunction in systemic sclerosis: time and frequency domain 24 hour heart rate variability analysis / Ferri, Clodoveo; Emdin, M; Giuggioli, D; Carpeggiani, C; Maielli, M.. - In: BRITISH JOURNAL OF RHEUMATOLOGY. - ISSN 0263-7103. - STAMPA. - 36:(1997), pp. 669-676.

Autonomic dysfunction in systemic sclerosis: time and frequency domain 24 hour heart rate variability analysis

FERRI, Clodoveo;GIUGGIOLI D;
1997

Abstract

To evaluate the autonomic nervous control of the heart in patients with systemic sclerosis (SSc), spontaneous heart rate variability was investigated by means of time-domain and spectrum analysis of 24 h ECG ambulatory recordings in 30 SSc patients (four males, aged 45.2 +/- 9 yr, mean +/- S.D., range 27-60) and 30 age-matched healthy subjects. A significantly higher heart rate (P < 0.01) and lower circadian and spectral indices of heart rate variability (P < 0.01) were observed in SSc patients, compared with controls. A predictive value of age (P = 0.002), tachycardia (P = 0.002), circadian heart rate variability (P = 0.0025) and spectral power values (P = 0.005) for patient mortality was found. Moreover, the relative risk of death was higher (P = 0.05) in older subjects with circulating anti-Scl70. These abnormalities, detectable by a feasible, non-invasive diagnostic approach, indicate the presence of autonomic cardiac neuropathy in SSc patients
1997
36
669
676
Autonomic dysfunction in systemic sclerosis: time and frequency domain 24 hour heart rate variability analysis / Ferri, Clodoveo; Emdin, M; Giuggioli, D; Carpeggiani, C; Maielli, M.. - In: BRITISH JOURNAL OF RHEUMATOLOGY. - ISSN 0263-7103. - STAMPA. - 36:(1997), pp. 669-676.
Ferri, Clodoveo; Emdin, M; Giuggioli, D; Carpeggiani, C; Maielli, M.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/452225
Citazioni
  • ???jsp.display-item.citation.pmc??? 15
  • Scopus 98
  • ???jsp.display-item.citation.isi??? 79
social impact