The solid-state transition kinetics to stable form FI of the two metastable polymorphs FII and FIII of chloramphenicol stearate and the transition kinetics from FII to FIII were studied, and a conversion mechanism was hypothesized.The elaboration of the data obtained enabled us to suggest a method for the calculation of thermodinamic and instantaneous transition temperatures from the metastable polymorph FII of chloramphenicol stearate to FIII.The energies of activation in the considered transformations and the stability at room temperature of the two metastable polymorphs in the solid-state were calculated.
Polymorphism of chloramphenicol stearate - II - Kinetics of solid-state transition of crystal forms / Cameroni, Riccardo; Bernabei, Maria Teresa; Forni, Flavio; Coppi, Gilberto. - In: IL FARMACO. EDIZIONE PRATICA. - ISSN 0430-0912. - STAMPA. - 33:(1978), pp. 447-454.
Polymorphism of chloramphenicol stearate - II - Kinetics of solid-state transition of crystal forms
CAMERONI, Riccardo;BERNABEI, Maria Teresa;FORNI, Flavio;COPPI, Gilberto
1978
Abstract
The solid-state transition kinetics to stable form FI of the two metastable polymorphs FII and FIII of chloramphenicol stearate and the transition kinetics from FII to FIII were studied, and a conversion mechanism was hypothesized.The elaboration of the data obtained enabled us to suggest a method for the calculation of thermodinamic and instantaneous transition temperatures from the metastable polymorph FII of chloramphenicol stearate to FIII.The energies of activation in the considered transformations and the stability at room temperature of the two metastable polymorphs in the solid-state were calculated.
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