Phenylbutazone (PB) Form IV is chemically and physically stable in solid drug dispersions with polyethylene glycol (PEG) 20,000 abtained by either fusion or solvent method. Moreover, the formation of a simple eutectic mixture at a (0.2:0.8) drug-carrier ratio was shown.The drug availability is always higher in the presence of the carrier. However, the drug dissolution rate from the physical mixtures and the solid dispersions is different according to the dissolution medium.
Solid phenylbutazone dispersions in polyethylene glycol 20,000 / Forni, Flavio; Iannuccelli, Valentina; Coppi, Gilberto; Bernabei, Maria Teresa. - In: PHARMAZEUTISCHE INDUSTRIE. - ISSN 0031-711X. - STAMPA. - 50:(1988), pp. 1405-1408.
Solid phenylbutazone dispersions in polyethylene glycol 20,000
FORNI, Flavio;IANNUCCELLI, Valentina;COPPI, Gilberto;BERNABEI, Maria Teresa
1988
Abstract
Phenylbutazone (PB) Form IV is chemically and physically stable in solid drug dispersions with polyethylene glycol (PEG) 20,000 abtained by either fusion or solvent method. Moreover, the formation of a simple eutectic mixture at a (0.2:0.8) drug-carrier ratio was shown.The drug availability is always higher in the presence of the carrier. However, the drug dissolution rate from the physical mixtures and the solid dispersions is different according to the dissolution medium.
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