Ethylene vinyl acetate pellets were loaded by swelling with chloroformic solutions of tolbutamide. The energy dispersive X-ray analysis showed different concentrations of the tolbutamide sulfur in the pellet sections according to the loading time. The concentration peaks might depend on a drug sieving process as the solution flow reaches a less swollen inner area. Another possible explanation of these concentration profiles is that they could be a result of thesolvent evaporation process. The concentration distribution of the drug becomes homogenous only after the complete swelling of all the polymer.

Distribution of drugs in polymers loaded by swelling / Forni, Flavio; Coppi, Gilberto; Iannuccelli, Valentina; Vandelli, Maria Angela; Bernabei, Maria Teresa. - In: JOURNAL OF PHARMACEUTICAL SCIENCES. - ISSN 0022-3549. - STAMPA. - 78:(1989), pp. 25-27. [10.1002/jps.2600780108]

Distribution of drugs in polymers loaded by swelling

FORNI, Flavio;COPPI, Gilberto;IANNUCCELLI, Valentina;VANDELLI, Maria Angela;BERNABEI, Maria Teresa
1989

Abstract

Ethylene vinyl acetate pellets were loaded by swelling with chloroformic solutions of tolbutamide. The energy dispersive X-ray analysis showed different concentrations of the tolbutamide sulfur in the pellet sections according to the loading time. The concentration peaks might depend on a drug sieving process as the solution flow reaches a less swollen inner area. Another possible explanation of these concentration profiles is that they could be a result of thesolvent evaporation process. The concentration distribution of the drug becomes homogenous only after the complete swelling of all the polymer.
1989
78
25
27
Distribution of drugs in polymers loaded by swelling / Forni, Flavio; Coppi, Gilberto; Iannuccelli, Valentina; Vandelli, Maria Angela; Bernabei, Maria Teresa. - In: JOURNAL OF PHARMACEUTICAL SCIENCES. - ISSN 0022-3549. - STAMPA. - 78:(1989), pp. 25-27. [10.1002/jps.2600780108]
Forni, Flavio; Coppi, Gilberto; Iannuccelli, Valentina; Vandelli, Maria Angela; Bernabei, Maria Teresa
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/450239
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