Active suppression of tumor-specific T lymphocytes can limit the efficacy of immune surveillance and immunotherapy. While tumor-recruited CD11b(+) myeloid cells are known mediators of tumor-associated immune dysfunction, the true nature of these suppressive cells and the fine biochemical pathways governing their immunosuppressive activity remain elusive. Here we describe a population of circulating CD11b(+)IL-4 receptor alpha(+) (CD 11b(+)IL-4R alpha(+)), inflammatory-type monocytes that is elicited by growing tumors and activated by IFN-gamma released from T lymphocytes. CD11b(+)IL-4R alpha(+) cells produced IL-13 and IFN-gamma and integrated the downstream signals of these cytokines to trigger the molecular pathways suppressing antigen-activated CD8(+) T lymphocytes. Analogous immunosuppressive circuits were active in CD11b(+) cells present within the tumor microenvironment. These suppressor cells challenge the current idea that tumor-conditioned immunosuppressive monocytes/macrophages are alternatively activated. Moreover, our data show how the inflammatory response elicited by tumors had detrimental effects on the adaptive immune system and suggest novel approaches for the treatment of tumor-induced immune dysfunctions.

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8(+) T cells / Gallina, G; Dolcetti, L; Serafini, P; DE SANTO, C; Marigo, I; Colombo, Mp; Basso, G; Brombacher, F; Borrello, I; Zanovello, P; Bicciato, Silvio; Bronte, V.. - In: THE JOURNAL OF CLINICAL INVESTIGATION. - ISSN 0021-9738. - STAMPA. - 116:(2006), pp. 2777-2790. [10.1172/JCI28828]

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8(+) T cells

BICCIATO, Silvio;
2006

Abstract

Active suppression of tumor-specific T lymphocytes can limit the efficacy of immune surveillance and immunotherapy. While tumor-recruited CD11b(+) myeloid cells are known mediators of tumor-associated immune dysfunction, the true nature of these suppressive cells and the fine biochemical pathways governing their immunosuppressive activity remain elusive. Here we describe a population of circulating CD11b(+)IL-4 receptor alpha(+) (CD 11b(+)IL-4R alpha(+)), inflammatory-type monocytes that is elicited by growing tumors and activated by IFN-gamma released from T lymphocytes. CD11b(+)IL-4R alpha(+) cells produced IL-13 and IFN-gamma and integrated the downstream signals of these cytokines to trigger the molecular pathways suppressing antigen-activated CD8(+) T lymphocytes. Analogous immunosuppressive circuits were active in CD11b(+) cells present within the tumor microenvironment. These suppressor cells challenge the current idea that tumor-conditioned immunosuppressive monocytes/macrophages are alternatively activated. Moreover, our data show how the inflammatory response elicited by tumors had detrimental effects on the adaptive immune system and suggest novel approaches for the treatment of tumor-induced immune dysfunctions.
2006
116
2777
2790
Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8(+) T cells / Gallina, G; Dolcetti, L; Serafini, P; DE SANTO, C; Marigo, I; Colombo, Mp; Basso, G; Brombacher, F; Borrello, I; Zanovello, P; Bicciato, Silvio; Bronte, V.. - In: THE JOURNAL OF CLINICAL INVESTIGATION. - ISSN 0021-9738. - STAMPA. - 116:(2006), pp. 2777-2790. [10.1172/JCI28828]
Gallina, G; Dolcetti, L; Serafini, P; DE SANTO, C; Marigo, I; Colombo, Mp; Basso, G; Brombacher, F; Borrello, I; Zanovello, P; Bicciato, Silvio; Bronte, V.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/421760
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