Abstract: The present review summarizes findings on stress-induced cell death in the IPLB-LdFB insect cell line derived from the larvalfat body of the lepidopteron Lymantria dispar. Apoptotic, oncotic and autophagic cell death have been described in these cells as a consequenceof oxidative stress or ATP deprivation, and similarities between IPLB-LdFB and mammalian apoptotic pathways have beenhighlighted. Furthermore, starting from observations in the IPLB-LdFB cells, a link has been surmised between relevance of autophagiccell death and developmental processes in the metazoan taxa.
Cell death in the IPLB-LdFB insect cell line: Facts and implications / Malagoli, Davide. - In: CURRENT PHARMACEUTICAL DESIGN. - ISSN 1381-6128. - STAMPA. - 14:2(2008), pp. 126-130. [10.2174/138161208783378752]
Cell death in the IPLB-LdFB insect cell line: Facts and implications
MALAGOLI, Davide
2008
Abstract
Abstract: The present review summarizes findings on stress-induced cell death in the IPLB-LdFB insect cell line derived from the larvalfat body of the lepidopteron Lymantria dispar. Apoptotic, oncotic and autophagic cell death have been described in these cells as a consequenceof oxidative stress or ATP deprivation, and similarities between IPLB-LdFB and mammalian apoptotic pathways have beenhighlighted. Furthermore, starting from observations in the IPLB-LdFB cells, a link has been surmised between relevance of autophagiccell death and developmental processes in the metazoan taxa.
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