Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the regulation of proliferation and differentiation of hematopoietic cells and in the pathogenesis of many diseases, including multiple myeloma. This study pursues a way to interfere with IL-6 pathway in an attempt to modulate its biological activity. Here we describe the rational design and biological evaluation of peptides able to antagonize the murine IL-6 activity by interfering with IL-6 Receptor alpha in 7TD1 cells, a IL-6-dependent B-cell line. Of the peptide tested, only Guess 4a is capable of interfering with IL-6 transducing pathway, therefore inducing growth arrest and apoptosis of 7TD1 cells.

Development of an IL-6 antagonist peptide that induces apoptosis in IL-6 dependent 7TD1 cells / Manfredini, Rossella; Tenedini, Elena; M., Siena; Tagliafico, Enrico; Montanari, Monica; Grande, Alexis; Zanocco Marani, Tommaso; C., Poligani; Zini, Roberta; A., Bergamaschi; De Rienzo, Francesca; De Benedetti, Pier Giuseppe; Menziani, Maria Cristina; Ferrari, Sergio. - In: PEPTIDES. - ISSN 0079-0753. - STAMPA. - 24:(2003), pp. 1207-1220. [10.1016/j.peptides.2003.06.005]

Development of an IL-6 antagonist peptide that induces apoptosis in IL-6 dependent 7TD1 cells.

MANFREDINI, Rossella;TENEDINI, Elena;TAGLIAFICO, Enrico;MONTANARI, Monica;GRANDE, Alexis;ZANOCCO MARANI, Tommaso;ZINI, Roberta;DE RIENZO, Francesca;DE BENEDETTI, Pier Giuseppe;MENZIANI, Maria Cristina;FERRARI, Sergio
2003

Abstract

Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the regulation of proliferation and differentiation of hematopoietic cells and in the pathogenesis of many diseases, including multiple myeloma. This study pursues a way to interfere with IL-6 pathway in an attempt to modulate its biological activity. Here we describe the rational design and biological evaluation of peptides able to antagonize the murine IL-6 activity by interfering with IL-6 Receptor alpha in 7TD1 cells, a IL-6-dependent B-cell line. Of the peptide tested, only Guess 4a is capable of interfering with IL-6 transducing pathway, therefore inducing growth arrest and apoptosis of 7TD1 cells.
24
1207
1220
Development of an IL-6 antagonist peptide that induces apoptosis in IL-6 dependent 7TD1 cells / Manfredini, Rossella; Tenedini, Elena; M., Siena; Tagliafico, Enrico; Montanari, Monica; Grande, Alexis; Zanocco Marani, Tommaso; C., Poligani; Zini, Roberta; A., Bergamaschi; De Rienzo, Francesca; De Benedetti, Pier Giuseppe; Menziani, Maria Cristina; Ferrari, Sergio. - In: PEPTIDES. - ISSN 0079-0753. - STAMPA. - 24:(2003), pp. 1207-1220. [10.1016/j.peptides.2003.06.005]
Manfredini, Rossella; Tenedini, Elena; M., Siena; Tagliafico, Enrico; Montanari, Monica; Grande, Alexis; ZANOCCO MARANI, Tommaso; C., Poligani; Zini, Roberta; A., Bergamaschi; DE RIENZO, Francesca; DE BENEDETTI, Pier Giuseppe; Menziani, Maria Cristina; Ferrari, Sergio
File in questo prodotto:
File Dimensione Formato  
peptides2003.pdf

non disponibili

Dimensione 911.25 kB
Formato Unknown
911.25 kB Unknown   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/310775
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 13
  • ???jsp.display-item.citation.isi??? 12
social impact