AbstractIn an experimental model of volume-controlled hemorrhagic shock causing the death of all rats within 30 min, the intravenous (i.v.) bolus injection of the adrenocorticotropic hormone fragment 1-24 (ACTH-(1-24)) (160 μg/kg) induced a prompt and sustained improvement of cardiovascular and respiratory function, with 100% survival 2 h after treatment. Pretreatment with either haloperidol, 300 μg/kg i.v. (antagonist at dopamine D[1] and D[2] receptors), or (R)-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hemimaleate (SCH 23390), 50 μg/kg intraperitoneally (selective antagonist at dopamine D[1] receptors), significantly inhibited the effect of ACTH-(1-24)

Dopamine D1 receptors are involved in the ACTH-induced reversal of hemorrhagic shock / Bazzani, Carla; Nardi, Maria Grazia; F., Ferrante; Bertolini, Alfio; Guarini, Salvatore. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - vol. 253, no.3:(1994), pp. 303-306.

Dopamine D1 receptors are involved in the ACTH-induced reversal of hemorrhagic shock

BAZZANI, Carla;NARDI, Maria Grazia;BERTOLINI, Alfio;GUARINI, Salvatore
1994

Abstract

AbstractIn an experimental model of volume-controlled hemorrhagic shock causing the death of all rats within 30 min, the intravenous (i.v.) bolus injection of the adrenocorticotropic hormone fragment 1-24 (ACTH-(1-24)) (160 μg/kg) induced a prompt and sustained improvement of cardiovascular and respiratory function, with 100% survival 2 h after treatment. Pretreatment with either haloperidol, 300 μg/kg i.v. (antagonist at dopamine D[1] and D[2] receptors), or (R)-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hemimaleate (SCH 23390), 50 μg/kg intraperitoneally (selective antagonist at dopamine D[1] receptors), significantly inhibited the effect of ACTH-(1-24)
1994
vol. 253, no.3
303
306
Dopamine D1 receptors are involved in the ACTH-induced reversal of hemorrhagic shock / Bazzani, Carla; Nardi, Maria Grazia; F., Ferrante; Bertolini, Alfio; Guarini, Salvatore. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - vol. 253, no.3:(1994), pp. 303-306.
Bazzani, Carla; Nardi, Maria Grazia; F., Ferrante; Bertolini, Alfio; Guarini, Salvatore
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/309983
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 2
social impact