Tumour necrosis factor (TNF) secretory activity has been studied in the murine macrophage cell line ANA-1 following in vitro exposure to Candida albicans 200 kDa stress mannoprotein (SMP200). Treatment of ANA-1 murine macrophages with 200 kDa stress mannoprotein results in increased TNF secretion. The phenomenon is (i) dose- and time-dependent, (ii) abrogated by 200 kDa stress mannoprotein preincubation with a specific monoclonal antibody, and (iii) dependent on intact murine macrophage Ca2+/calmodulin-dependent protein kinase function.
Candida albicans stress mannoprotein, SMP 200, enhances tumor necrosis factor secretion in the murine macrophage cell line ANA-1 / L., Pitzurra; L., Polonelli; C., Cantelli; M., Gerloni; J., Ponton; J., Bikandi; Blasi, Elisabetta. - In: JOURNAL OF MEDICAL AND VETERINARY MYCOLOGY. - ISSN 0268-1218. - ELETTRONICO. - 34:(1996), pp. 219-222.
Candida albicans stress mannoprotein, SMP 200, enhances tumor necrosis factor secretion in the murine macrophage cell line ANA-1
BLASI, Elisabetta
1996
Abstract
Tumour necrosis factor (TNF) secretory activity has been studied in the murine macrophage cell line ANA-1 following in vitro exposure to Candida albicans 200 kDa stress mannoprotein (SMP200). Treatment of ANA-1 murine macrophages with 200 kDa stress mannoprotein results in increased TNF secretion. The phenomenon is (i) dose- and time-dependent, (ii) abrogated by 200 kDa stress mannoprotein preincubation with a specific monoclonal antibody, and (iii) dependent on intact murine macrophage Ca2+/calmodulin-dependent protein kinase function.
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