This study reports that in Schwann cell tissue culture the administration of the two pro-inflammatory cytokines, interleukin-1 beta (IL-1beta) and interferon-gamma (IFN-gamma), at different dosages, singly or in combination, can induce apoptosis and/or mitosis. Schwann cell apoptosis was maximal within 24 h of stimulation with 50 U/ml of IFN-gamma, while proliferation was at its peak within 24 h with 10 U/ml IL-1beta, and both processes decreased progressively by 48 and 72 h. Moreover, the combination of the two cytokines did not show any synergistic effect. These data can be interpreted as a possible involvement of pro-inflammatory cytokines not only in myelin disruption but also in promoting remyelination. (C) 2002 Elsevier Science B.V. All rights reserved.
Interleukin-1 beta and interferon-gamma induce proliferation and apoptosis in cultured Schwann cells / G., Conti; DE POL, Anto; E., Scarpini; F., Vaccina; M., De Riz; P., Baron; M., Tiriticco; G., Scarlato. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - STAMPA. - 124:1-2(2002), pp. 29-35. [10.1016/S0165-5728(02)00003-6]
Interleukin-1 beta and interferon-gamma induce proliferation and apoptosis in cultured Schwann cells
DE POL, Anto;
2002
Abstract
This study reports that in Schwann cell tissue culture the administration of the two pro-inflammatory cytokines, interleukin-1 beta (IL-1beta) and interferon-gamma (IFN-gamma), at different dosages, singly or in combination, can induce apoptosis and/or mitosis. Schwann cell apoptosis was maximal within 24 h of stimulation with 50 U/ml of IFN-gamma, while proliferation was at its peak within 24 h with 10 U/ml IL-1beta, and both processes decreased progressively by 48 and 72 h. Moreover, the combination of the two cytokines did not show any synergistic effect. These data can be interpreted as a possible involvement of pro-inflammatory cytokines not only in myelin disruption but also in promoting remyelination. (C) 2002 Elsevier Science B.V. All rights reserved.
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