To assess the prognosis of peripheral T-cell lymphoma unspecified, we retrospectively analyzed 385 cases fulfilling the criteria defined by the World Health Organization classification. Factors associated with a worse overall survival (OS) in a univariate analysis were age older than 60 years (P=.0002), equal to or more than 2 extranodal sites (P=.0002), lactic dehydrogenase (LDH) value at normal levels or above (P<.0001), performance status (PS) equal to or more than 2 (Pless than or equal to.0001), stage III or higher (P=.0001), and bone marrow involvement (P=.0001). Multivariate analysis showed that age (relative risk, 1.732; 95% CI, 1.300-2.309; P<.0001), PS (relative risk, 1.719; 95% CI, 1.269-2.327, P<.0001), LDH level (relative risk, 1.905; 95% CI, 1.415-2.564; P<.0001), and bone marrow involvement (relative risk, 1.454; 95% CI, 1.045-2.023; P=.026) were factors independently predictive for survival. Using these 4 variables we constructed a new prognostic model that singled out 4 groups at different risk: group 1, no adverse factors, with 5-year and 10-year OS of 62.3% and 54.9%, respectively; group 2, one factor, with a 5-year and 10-year OS of 52.9% and 38.8%, respectively; group 3, 2 factors, with 5-year and 10-year OS of 32.9% and 18.0%, respectively; group 4,3 or 4 factors, with a 5-year and 10-year OS of 18.3 and 12.6%, respectively (Pless than or equal to.0001; log-rank, 66.79).

Peripheral T-cell lymphoma unspecified (PTCL-U): a new prognostic model from a retrospective multicentric clinical study / A., Gallamini; C., Stelitano; R., Calvi; Bellei, Monica; D., Mattei; U., Vitolo; F., Morabito; M., Martelli; E., Brusamolino; E., Iannitto; F., Zaja; S., Cortelazzo; L., Rigacci; L., Devizzi; G., Todeschini; G., Santini; M., Brugiatelli; Federico, Massimo. - In: BLOOD. - ISSN 0006-4971. - STAMPA. - 103 (7):(2004), pp. 2474-2479. [10.1182/blood-2003-09-3080]

Peripheral T-cell lymphoma unspecified (PTCL-U): a new prognostic model from a retrospective multicentric clinical study

BELLEI, Monica;FEDERICO, Massimo
2004

Abstract

To assess the prognosis of peripheral T-cell lymphoma unspecified, we retrospectively analyzed 385 cases fulfilling the criteria defined by the World Health Organization classification. Factors associated with a worse overall survival (OS) in a univariate analysis were age older than 60 years (P=.0002), equal to or more than 2 extranodal sites (P=.0002), lactic dehydrogenase (LDH) value at normal levels or above (P<.0001), performance status (PS) equal to or more than 2 (Pless than or equal to.0001), stage III or higher (P=.0001), and bone marrow involvement (P=.0001). Multivariate analysis showed that age (relative risk, 1.732; 95% CI, 1.300-2.309; P<.0001), PS (relative risk, 1.719; 95% CI, 1.269-2.327, P<.0001), LDH level (relative risk, 1.905; 95% CI, 1.415-2.564; P<.0001), and bone marrow involvement (relative risk, 1.454; 95% CI, 1.045-2.023; P=.026) were factors independently predictive for survival. Using these 4 variables we constructed a new prognostic model that singled out 4 groups at different risk: group 1, no adverse factors, with 5-year and 10-year OS of 62.3% and 54.9%, respectively; group 2, one factor, with a 5-year and 10-year OS of 52.9% and 38.8%, respectively; group 3, 2 factors, with 5-year and 10-year OS of 32.9% and 18.0%, respectively; group 4,3 or 4 factors, with a 5-year and 10-year OS of 18.3 and 12.6%, respectively (Pless than or equal to.0001; log-rank, 66.79).
2004
103 (7)
2474
2479
Peripheral T-cell lymphoma unspecified (PTCL-U): a new prognostic model from a retrospective multicentric clinical study / A., Gallamini; C., Stelitano; R., Calvi; Bellei, Monica; D., Mattei; U., Vitolo; F., Morabito; M., Martelli; E., Brusamolino; E., Iannitto; F., Zaja; S., Cortelazzo; L., Rigacci; L., Devizzi; G., Todeschini; G., Santini; M., Brugiatelli; Federico, Massimo. - In: BLOOD. - ISSN 0006-4971. - STAMPA. - 103 (7):(2004), pp. 2474-2479. [10.1182/blood-2003-09-3080]
A., Gallamini; C., Stelitano; R., Calvi; Bellei, Monica; D., Mattei; U., Vitolo; F., Morabito; M., Martelli; E., Brusamolino; E., Iannitto; F., Zaja; S., Cortelazzo; L., Rigacci; L., Devizzi; G., Todeschini; G., Santini; M., Brugiatelli; Federico, Massimo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/306057
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