Impairment in cholinergic systems is a highly consistent finding in human dementia. Among cholinergic markers, marked decreases in nicotine binding have been most consistently observed in the telencephalic regions of demented patients and are thought to contribute to the cognitive deficits associated with ageing and age-related neurodegenerative diseases. New evidence that the cholinergic system has a specific pathogenic role in the neurodegenerative alterations of aged and, especially, demented patients is fast accumulating. Both in vivo and in culture, nicotine protects striatal, hippocampal and cortical neurons against the neurotoxicity induced by excitotoxic amino acids as well as the toxicity caused by beta-amyloid, the major component of senile plaques. Further support for the implication of nicotinic receptors in brain ageing is come from recent studies on transgenic animals lacking nicotinic receptor subtypes, which shed light on the mechanisms of nicotine neuroprotection and neurotoxicity. (C) 2002 Published by Elsevier Science Ireland Ltd.

Nicotine and neurodegeneration in ageing / Zanardi, Alessio; Leo, Giuseppina; Biagini, Giuseppe; Zoli, Michele. - In: TOXICOLOGY LETTERS. - ISSN 0378-4274. - STAMPA. - 127:1-3(2002), pp. 207-215. [10.1016/S0378-4274(01)00502-1]

Nicotine and neurodegeneration in ageing

ZANARDI, Alessio;LEO, Giuseppina;BIAGINI, Giuseppe;ZOLI, Michele
2002

Abstract

Impairment in cholinergic systems is a highly consistent finding in human dementia. Among cholinergic markers, marked decreases in nicotine binding have been most consistently observed in the telencephalic regions of demented patients and are thought to contribute to the cognitive deficits associated with ageing and age-related neurodegenerative diseases. New evidence that the cholinergic system has a specific pathogenic role in the neurodegenerative alterations of aged and, especially, demented patients is fast accumulating. Both in vivo and in culture, nicotine protects striatal, hippocampal and cortical neurons against the neurotoxicity induced by excitotoxic amino acids as well as the toxicity caused by beta-amyloid, the major component of senile plaques. Further support for the implication of nicotinic receptors in brain ageing is come from recent studies on transgenic animals lacking nicotinic receptor subtypes, which shed light on the mechanisms of nicotine neuroprotection and neurotoxicity. (C) 2002 Published by Elsevier Science Ireland Ltd.
2002
127
1-3
207
215
Nicotine and neurodegeneration in ageing / Zanardi, Alessio; Leo, Giuseppina; Biagini, Giuseppe; Zoli, Michele. - In: TOXICOLOGY LETTERS. - ISSN 0378-4274. - STAMPA. - 127:1-3(2002), pp. 207-215. [10.1016/S0378-4274(01)00502-1]
Zanardi, Alessio; Leo, Giuseppina; Biagini, Giuseppe; Zoli, Michele
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/305750
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