Objective: Pregnancy-induced hypertension with proteinuria (preeclampsia-PE) is linked to increased vascular reactivity, increased vasoconstrictors, endothelial damage and platelet hyperaggregation, which are also typical features of migraine patients. Thus, we investigated the association between headache and PE. Methods: In a case-control study, we evaluated the occurrence of primary headache forms in 75 women with a recent history of PE. Seventy-five controls were selected from women having uneventful pregnancy at term. Both groups were matched for age and parity. Subjects´ headache history was evaluated by using an ad hoe structured questionnaire. The International Headache Society criteria for primary headaches were applied to diagnose the specific form of headache. Results: In PE cases, gestational age at parturition was 34.2 +/- 3.8 weeks and birthweight was 1820 +/- 746 g, whereas in controls they were 39.3 +/- 1.5 weeks and 3365 +/- 437 g, respectively (P < 0.01). Sixty-six (44 %) subjects suffered from headache. Headache was significantly more frequent in PE (47/75) than in controls (19/75), OR 4.95 (95 % Cl, 2.47-9.92). Migraine without aura was more frequently present in cases than in controls while episodic tension-type headache was equally distributed among groups. Fifty-two patients met the criteria of severe PE. The number of patients suffering from headache was significantly higher in severe patients (39 cases, 75 %) than in those with moderate PE (8 cases, 34.8 %), OR = 5.63 (95 % CL 1.97-16.03). With respect to controls, PE patients reported a more frequent onset at menarche, more menstrually related attacks and an increased rate of improvement during pregnancy. Conclusion: This study shows that there is a strong association between migraine history and PE development, namely with the severe form of PE.
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|Anno di pubblicazione:||2005|
|Titolo:||The relationship between headache and preeclampsia: a case-control study|
|Autori:||F. FACCHINETTI; G. ALLAIS; R. D'AMICO; C. BENEDETTO; A. VOLPE|
|Appare nelle tipologie:||Articolo su rivista|
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