In a rat model of hemorrhagic shock which caused the death of all control rats within 30 min, i.v. injection of the ganglion-stimulating drug dimethylphenylpiperazinium (DMPP) caused a dose-dependent reversal of the shock condition - without the need for reinfusion of the shed blood - starting from the dose of 4 ng/kg i.v. Shock reversal was associated with the mobilization of residual blood and improvement in blood flow, particularly at the carotid level. These results could influence our thinking on pathophysiology and first-aid management of shock.
Reversal of experimental hemorrhagic shock by dimethylphenylpiperazinium (DMPP) / Guarini, Salvatore; Bazzani, Carla; S., Tagliavini; Bertolini, Alfio; Ferrari, William. - In: EXPERIENTIA. - ISSN 0014-4754. - STAMPA. - 48:(1992), pp. 663-667.
Reversal of experimental hemorrhagic shock by dimethylphenylpiperazinium (DMPP)
GUARINI, Salvatore;BAZZANI, Carla;BERTOLINI, Alfio;FERRARI, William
1992
Abstract
In a rat model of hemorrhagic shock which caused the death of all control rats within 30 min, i.v. injection of the ganglion-stimulating drug dimethylphenylpiperazinium (DMPP) caused a dose-dependent reversal of the shock condition - without the need for reinfusion of the shed blood - starting from the dose of 4 ng/kg i.v. Shock reversal was associated with the mobilization of residual blood and improvement in blood flow, particularly at the carotid level. These results could influence our thinking on pathophysiology and first-aid management of shock.Pubblicazioni consigliate
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