It has been recently demonstrated that Candida albicans isolates with distinct genomic backgrounds (namely, b and c genotypes) press different susceptibility to antifungal activity by human monocytes in vitro. We show here that, although comparable in their ability to undergo dimorphic transition and in susceptibility to phagocytosis by microglial cells, the b and c isolates show striking differences in terms of intracellular survival. Only the c genotype resists indeed to intracellular killing and eventually replicates inside microglial cells, that in turn respond to fungal infection, preferentially towards the c genotype, with nuclear factor-kappa B (NF-kappa B) activation and increased Mip1 alpha production. These data indicate that C albicans-microglial cell interaction is strictly dependent upon fungal genotype, strengthening the potential significance of genotyping as prognostic parameter in clinical infections by C albicans. (c) 2006 Elsevier Ltd. All rights reserved.

Adaptive response of microglial cells to in vitro infection by Candida albicans isolates with different genomic backgrounds / Neglia, Rachele Giovanna; Colombari, Bruna; Peppoloni, Samuele; Orsi, Carlotta Francesca; A., Tavanti; S., Senesi; Blasi, Elisabetta. - In: MICROBIAL PATHOGENESIS. - ISSN 0882-4010. - STAMPA. - 41:6(2006), pp. 251-256. [10.1016/j.micpath.2006.08.001]

Adaptive response of microglial cells to in vitro infection by Candida albicans isolates with different genomic backgrounds

NEGLIA, Rachele Giovanna;COLOMBARI, Bruna;PEPPOLONI, Samuele;ORSI, Carlotta Francesca;BLASI, Elisabetta
2006

Abstract

It has been recently demonstrated that Candida albicans isolates with distinct genomic backgrounds (namely, b and c genotypes) press different susceptibility to antifungal activity by human monocytes in vitro. We show here that, although comparable in their ability to undergo dimorphic transition and in susceptibility to phagocytosis by microglial cells, the b and c isolates show striking differences in terms of intracellular survival. Only the c genotype resists indeed to intracellular killing and eventually replicates inside microglial cells, that in turn respond to fungal infection, preferentially towards the c genotype, with nuclear factor-kappa B (NF-kappa B) activation and increased Mip1 alpha production. These data indicate that C albicans-microglial cell interaction is strictly dependent upon fungal genotype, strengthening the potential significance of genotyping as prognostic parameter in clinical infections by C albicans. (c) 2006 Elsevier Ltd. All rights reserved.
2006
41
6
251
256
Adaptive response of microglial cells to in vitro infection by Candida albicans isolates with different genomic backgrounds / Neglia, Rachele Giovanna; Colombari, Bruna; Peppoloni, Samuele; Orsi, Carlotta Francesca; A., Tavanti; S., Senesi; Blasi, Elisabetta. - In: MICROBIAL PATHOGENESIS. - ISSN 0882-4010. - STAMPA. - 41:6(2006), pp. 251-256. [10.1016/j.micpath.2006.08.001]
Neglia, Rachele Giovanna; Colombari, Bruna; Peppoloni, Samuele; Orsi, Carlotta Francesca; A., Tavanti; S., Senesi; Blasi, Elisabetta
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/304816
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