Failure of tamoxifen treatment for unresectable hepatocellular carcinomas (HCCs) might be caused by variant estrogen receptors (ERs) in some of these tumors. We therefore planned a study in which antihormonal therapy was done with 80 mg/day tamoxifen or 160 mg/day megestrol according to the presence of wild-type or exon 5-deleted variant ER transcripts. Growth rate (evaluated by MRI) of HCCs characterized by variant ER transcripts was 4 times more rapid than that of HCCs with wild-type ERs. Tumor volume in all patients with wild-type ERs was halved after 9 months of tamoxifen treatment, whereas megestrol in patients with variant ERs only slowed down tumor growth. Choosing antihormonal treatment according to the presence of wild-type or variant ERs in the tumor definitely improves the response rate to tamoxifen; in patients with tumors bearing variant ERs, megestrol causes only a temporary inhibition of tumor growth.

Type of estrogen receptor determines response to antiestrogen therapy / Villa, Erica; A., Dugani; E., Fantoni; L., Camellini; P., Buttafoco; Grottola, Antonella; G., Pompei; M., Desantis; Ferrari, Alberto; Manenti, Federico. - In: CANCER RESEARCH. - ISSN 0008-5472. - STAMPA. - 56:(1996), pp. 3883-3885.

Type of estrogen receptor determines response to antiestrogen therapy

VILLA, Erica;GROTTOLA, Antonella;FERRARI, Alberto;MANENTI, Federico
1996

Abstract

Failure of tamoxifen treatment for unresectable hepatocellular carcinomas (HCCs) might be caused by variant estrogen receptors (ERs) in some of these tumors. We therefore planned a study in which antihormonal therapy was done with 80 mg/day tamoxifen or 160 mg/day megestrol according to the presence of wild-type or exon 5-deleted variant ER transcripts. Growth rate (evaluated by MRI) of HCCs characterized by variant ER transcripts was 4 times more rapid than that of HCCs with wild-type ERs. Tumor volume in all patients with wild-type ERs was halved after 9 months of tamoxifen treatment, whereas megestrol in patients with variant ERs only slowed down tumor growth. Choosing antihormonal treatment according to the presence of wild-type or variant ERs in the tumor definitely improves the response rate to tamoxifen; in patients with tumors bearing variant ERs, megestrol causes only a temporary inhibition of tumor growth.
1996
56
3883
3885
Type of estrogen receptor determines response to antiestrogen therapy / Villa, Erica; A., Dugani; E., Fantoni; L., Camellini; P., Buttafoco; Grottola, Antonella; G., Pompei; M., Desantis; Ferrari, Alberto; Manenti, Federico. - In: CANCER RESEARCH. - ISSN 0008-5472. - STAMPA. - 56:(1996), pp. 3883-3885.
Villa, Erica; A., Dugani; E., Fantoni; L., Camellini; P., Buttafoco; Grottola, Antonella; G., Pompei; M., Desantis; Ferrari, Alberto; Manenti, Federico
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/304713
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