The benzoylamino group was identified as a useful radical cyclization auxiliary that can be smoothly removed on hydro-dehalogenation of chlorinated N-substituted-pyrrolidin-2-ones with Raney-Ni. This methodology was successfully implemented in a new and appealing route to the anti-epileptic drug gabapentin.
Hydro-de-halogenation and consecutive deprotection of chlorinated N-amido-pyrrolidin-2-ones with Raney-Ni: an effective approach to gabapentin / R., Cagnoli; Ghelfi, Franco; Pagnoni, Ugo Maria; Af, Parsons; Schenetti, Luisa. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 59:50(2003), pp. 9951-9960. [10.1016/j.tet.2003.10.046]
Hydro-de-halogenation and consecutive deprotection of chlorinated N-amido-pyrrolidin-2-ones with Raney-Ni: an effective approach to gabapentin
GHELFI, Franco;PAGNONI, Ugo Maria;SCHENETTI, Luisa
2003
Abstract
The benzoylamino group was identified as a useful radical cyclization auxiliary that can be smoothly removed on hydro-dehalogenation of chlorinated N-substituted-pyrrolidin-2-ones with Raney-Ni. This methodology was successfully implemented in a new and appealing route to the anti-epileptic drug gabapentin.
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