It is now well accepted that endogenous morphine is present in animals, both in invertebrates and vertebrates. It is a key signal molecule that plays an important role in downregulating physiological responses, such as those in the immune system, including immune elements in the CNS. It has been demonstrated that a specific mu-opiate-receptor subtype mu3, mediates these downregulatory effects through release of NO. This article examines morphine as an endogenous signaling molecule, in terms of its role in neural and immune regulation.
Endogenous morphine / Stefano, G. B.; Goumon, Y.; Casares, F.; Cad, P.; Fricchione, G. L.; Rialas, G.; Peter, D.; Sonetti, Dario; Guarna, M.; Welters, I. D.; Bianchi, E.. - In: TRENDS IN NEUROSCIENCES. - ISSN 0166-2236. - STAMPA. - 23:9(2000), pp. 436-442. [10.1016/S0166-2236(00)01611-8]
Endogenous morphine
SONETTI, Dario;
2000
Abstract
It is now well accepted that endogenous morphine is present in animals, both in invertebrates and vertebrates. It is a key signal molecule that plays an important role in downregulating physiological responses, such as those in the immune system, including immune elements in the CNS. It has been demonstrated that a specific mu-opiate-receptor subtype mu3, mediates these downregulatory effects through release of NO. This article examines morphine as an endogenous signaling molecule, in terms of its role in neural and immune regulation.
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