We aimed to assess the occurrence of ghrelin, a new gut hormone, in endocrine growths of the stomach. In addition, since ghrelin has been detected in other gut derivatives during adult and/or fetal life, we also studied endocrine tumours of the pancreas, intestine and lung. A specific serum generated against amino acids 13-28 of ghrelin was tested on 16 specimens of gastric mucosa with endocrine cell hyperplasia and on 75 endocrine tumours. Ghrelin-immunoreactive cells were moderately represented in normal, atrophic or hypertrophic gastric mucosa, as a rule with no obvious hyperplastic changes even in the presence of concurrent, prominent enterochromaffin-like cell hyperplasia associated with hypergastrinemia. Ghrelin cells were also found in tumour cell fractions of well-differentiated gastric (25 of 33, 76%), pancreatic (6 of 15, 40%) and pulmonary (4 of 8) endocrine tumours. No ghrelin immunoreactivity was detected in 14 intestinal tumours and in five poorly differentiated endocrine carcinomas of the stomach or pancreas. We conclude that ghrelin cells may take part in gut endocrine growths, with special reference to well-differentiated endocrine tumours of the stomach, independently from associated signs of endocrine hyperfunction.

Ghrelin expression in gut endocrine growths / Rindi, G.; Savio, A.; Torsello, A.; Zoli, Michele; Locatelli, V.; Cocchi, D.; Paolotti, D.; Solcia, E.. - In: HISTOCHEMISTRY AND CELL BIOLOGY. - ISSN 0948-6143. - STAMPA. - 117:(2002), pp. 521-525. [10.1007/s00418-002-0416-0]

Ghrelin expression in gut endocrine growths

ZOLI, Michele;
2002

Abstract

We aimed to assess the occurrence of ghrelin, a new gut hormone, in endocrine growths of the stomach. In addition, since ghrelin has been detected in other gut derivatives during adult and/or fetal life, we also studied endocrine tumours of the pancreas, intestine and lung. A specific serum generated against amino acids 13-28 of ghrelin was tested on 16 specimens of gastric mucosa with endocrine cell hyperplasia and on 75 endocrine tumours. Ghrelin-immunoreactive cells were moderately represented in normal, atrophic or hypertrophic gastric mucosa, as a rule with no obvious hyperplastic changes even in the presence of concurrent, prominent enterochromaffin-like cell hyperplasia associated with hypergastrinemia. Ghrelin cells were also found in tumour cell fractions of well-differentiated gastric (25 of 33, 76%), pancreatic (6 of 15, 40%) and pulmonary (4 of 8) endocrine tumours. No ghrelin immunoreactivity was detected in 14 intestinal tumours and in five poorly differentiated endocrine carcinomas of the stomach or pancreas. We conclude that ghrelin cells may take part in gut endocrine growths, with special reference to well-differentiated endocrine tumours of the stomach, independently from associated signs of endocrine hyperfunction.
2002
117
521
525
Ghrelin expression in gut endocrine growths / Rindi, G.; Savio, A.; Torsello, A.; Zoli, Michele; Locatelli, V.; Cocchi, D.; Paolotti, D.; Solcia, E.. - In: HISTOCHEMISTRY AND CELL BIOLOGY. - ISSN 0948-6143. - STAMPA. - 117:(2002), pp. 521-525. [10.1007/s00418-002-0416-0]
Rindi, G.; Savio, A.; Torsello, A.; Zoli, Michele; Locatelli, V.; Cocchi, D.; Paolotti, D.; Solcia, E.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/20833
Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus 56
  • ???jsp.display-item.citation.isi??? 48
social impact