After a median of 37 months on antiretroviral therapy, 16 patients were asked to discontinue treatment instead of changing it. After a median observation time of 10.5 months, most patients experienced a rapid and progressive decrease in their CD4 cell count, even without a high viral load rebound. This decline was unrelated to the CD4 cell count and HIV-RNA values at interruption, but was more profound in patients in whom the M184V mutation had disappeared after lamivudine discontinuation.
Kinetics of CD4 cells after discontinuation of antiretroviral therapy in patients with virological failure and a CD4 cell count grater than 500 cells / Mussini, Cristina; Bugarini, R.; Perno, C. F.; Antinori, A.; Borghi, V.; Bertoli, A.; D`arrigo, R.; Bedini, A.; Cossarizza, Andrea; Esposito, Roberto. - In: AIDS. - ISSN 1473-5571. - ELETTRONICO. - 16:(2002), pp. 1551-1554.
Kinetics of CD4 cells after discontinuation of antiretroviral therapy in patients with virological failure and a CD4 cell count grater than 500 cells
MUSSINI, Cristina;COSSARIZZA, Andrea;ESPOSITO, Roberto
2002
Abstract
After a median of 37 months on antiretroviral therapy, 16 patients were asked to discontinue treatment instead of changing it. After a median observation time of 10.5 months, most patients experienced a rapid and progressive decrease in their CD4 cell count, even without a high viral load rebound. This decline was unrelated to the CD4 cell count and HIV-RNA values at interruption, but was more profound in patients in whom the M184V mutation had disappeared after lamivudine discontinuation.
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