In view of the increasing evidence that a variety of stresses can influence immune responses, the direct effect of adrenocorticotropic hormone on the migration of human monocytes was studied in vitro. ACTH(1-24) significantly increased the number of migrating cells when placed in the same or the opposite compartment of the chemotaxis chamber, maximum activity being obtained at 10(-14) and 10(-8) M. The results indicate that ACTH(1-24) directly and potently stimulates the migration of human monocytes by means of a chemokinetic effect.
ACTH(124) stimulates the migration of human monocytes in vitro / Genedani, Susanna; Bernardi, M.; Baldini, Mg; Bertolini, Alfio. - In: PEPTIDES. - ISSN 0196-9781. - STAMPA. - 11:(1990), pp. 1305-1307.
ACTH(124) stimulates the migration of human monocytes in vitro.
GENEDANI, Susanna;BERTOLINI, Alfio
1990
Abstract
In view of the increasing evidence that a variety of stresses can influence immune responses, the direct effect of adrenocorticotropic hormone on the migration of human monocytes was studied in vitro. ACTH(1-24) significantly increased the number of migrating cells when placed in the same or the opposite compartment of the chemotaxis chamber, maximum activity being obtained at 10(-14) and 10(-8) M. The results indicate that ACTH(1-24) directly and potently stimulates the migration of human monocytes by means of a chemokinetic effect.
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