Background and aims: Aphasia is a disabling consequence for 30% of ischemic stroke patients. The wide variability of recovery among post-stroke aphasic patients despite similar baseline stroke severity and clinical characteristics could be in part explained by the involvement of a sort of ‘Linguistic Cognitive Reserve’. Therefore, an informant-based questionnaire named “QuALiCoMe”, was developed by an interdisciplinary work based on various branches of linguistics, cognitive psychology, educational research and neurology, with the aim of estimating the pre-morbid linguistic abilities in patients with post-stroke aphasia. Methods: Validation of QuALiCoMe questionnaire on 182 healthy subjects (HS) and 82 respective caregiver/cohabitant (CC). Pilot study: Frenchay Aphasia Screening Test (FAST) was administered within 48 hours after stroke onset (baseline) and after 6-month follow-up, and QuALiCoMe was administered to aphasic patient’s CC. As explanatory variable for aphasia recovery, we used delta-FAST score (baseline – follow-up). Results: QuALiCoMe demonstrated a good informativeness and reliability (high concordance between HS and CC), applicability, internal consistency and external validity. Sixty stroke patients (29 female, mean NIHSS±DS= 14.30± 7.11, mean FAST±DS=10.02±9.61) fulfilled inclusion criteria. In a multivariate analysis, corrected for age, baseline-NIHSS, education, speech and language therapy, and thrombolysis, QuALiCoMe score showed a trend for significance in predicting recovery from aphasia (p=0.062). Conclusion: This result represents the first clinical evidence of the role of Linguistic Cognitive Reserve as an outcome predictor in post-stroke aphasia. QuALiCoMe demonstrates a valid and promising tool to estimate pre-morbid linguistic reserve in post-stroke aphasic patients. Its potential utility needs to be confirmed in larger cohorts of patients. Disclosure: This research has been granted by “Ente Cassa di Risparmio di Firenze”.

Linguistic cognitive reserve may influence post-stroke aphasia recovery and rehabilitation: the QuALicoMe study / Sodero, A; Carlucci, G; Favilla, M; Piccardi, B; Pracucci, G; Fedi, F; Marini, S; Pugliese, M; Milani, C; Inzitari, D. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1351-5101. - 27:S1(2020), pp. 40-40. (Intervento presentato al convegno European Stroke Organisation (ESO) - World Stroke Organisation (WSO) 2020 Conference tenutosi a Virtual nel 7-9 Novembre 2020) [10.1111/ene.14306].

Linguistic cognitive reserve may influence post-stroke aphasia recovery and rehabilitation: the QuALicoMe study

Favilla, M;
2020

Abstract

Background and aims: Aphasia is a disabling consequence for 30% of ischemic stroke patients. The wide variability of recovery among post-stroke aphasic patients despite similar baseline stroke severity and clinical characteristics could be in part explained by the involvement of a sort of ‘Linguistic Cognitive Reserve’. Therefore, an informant-based questionnaire named “QuALiCoMe”, was developed by an interdisciplinary work based on various branches of linguistics, cognitive psychology, educational research and neurology, with the aim of estimating the pre-morbid linguistic abilities in patients with post-stroke aphasia. Methods: Validation of QuALiCoMe questionnaire on 182 healthy subjects (HS) and 82 respective caregiver/cohabitant (CC). Pilot study: Frenchay Aphasia Screening Test (FAST) was administered within 48 hours after stroke onset (baseline) and after 6-month follow-up, and QuALiCoMe was administered to aphasic patient’s CC. As explanatory variable for aphasia recovery, we used delta-FAST score (baseline – follow-up). Results: QuALiCoMe demonstrated a good informativeness and reliability (high concordance between HS and CC), applicability, internal consistency and external validity. Sixty stroke patients (29 female, mean NIHSS±DS= 14.30± 7.11, mean FAST±DS=10.02±9.61) fulfilled inclusion criteria. In a multivariate analysis, corrected for age, baseline-NIHSS, education, speech and language therapy, and thrombolysis, QuALiCoMe score showed a trend for significance in predicting recovery from aphasia (p=0.062). Conclusion: This result represents the first clinical evidence of the role of Linguistic Cognitive Reserve as an outcome predictor in post-stroke aphasia. QuALiCoMe demonstrates a valid and promising tool to estimate pre-morbid linguistic reserve in post-stroke aphasic patients. Its potential utility needs to be confirmed in larger cohorts of patients. Disclosure: This research has been granted by “Ente Cassa di Risparmio di Firenze”.
2020
27
40
40
Sodero, A; Carlucci, G; Favilla, M; Piccardi, B; Pracucci, G; Fedi, F; Marini, S; Pugliese, M; Milani, C; Inzitari, D
Linguistic cognitive reserve may influence post-stroke aphasia recovery and rehabilitation: the QuALicoMe study / Sodero, A; Carlucci, G; Favilla, M; Piccardi, B; Pracucci, G; Fedi, F; Marini, S; Pugliese, M; Milani, C; Inzitari, D. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1351-5101. - 27:S1(2020), pp. 40-40. (Intervento presentato al convegno European Stroke Organisation (ESO) - World Stroke Organisation (WSO) 2020 Conference tenutosi a Virtual nel 7-9 Novembre 2020) [10.1111/ene.14306].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1254496
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