The injection of desmethylimipramine (DMI) twice daily for 3 weeks reduced the density of β-adrenergic receptor recognition sites located in crude synaptic membranes prepared from the cortex and hippocampus and attenuated the stimulation of the membrane-bound adenylate cyclase by isoproterenol. Both actions were abolished if prior to treatment with desmethylimipramine the serotonergic axons were destroyed by an intraventricular injection of 5,7-dihydroxytryptamine. These results show that the down-regulation of β-adrenergic receptors elicited by repeated injections of desmethylimipramine occurs only if the serotonergic axons are intact. © 1982.

Down-regulation of β-adrenergic receptors following repeated injections of desmethylimipramine: Permissive role of serotonergic axons / Brunello, N.; Barbaccia, M. L.; Chuang, D. -M.; Costa, E.. - In: NEUROPHARMACOLOGY. - ISSN 0028-3908. - 21:11(1982), pp. 1145-1149. [10.1016/0028-3908(82)90172-1]

Down-regulation of β-adrenergic receptors following repeated injections of desmethylimipramine: Permissive role of serotonergic axons

Brunello N.;
1982

Abstract

The injection of desmethylimipramine (DMI) twice daily for 3 weeks reduced the density of β-adrenergic receptor recognition sites located in crude synaptic membranes prepared from the cortex and hippocampus and attenuated the stimulation of the membrane-bound adenylate cyclase by isoproterenol. Both actions were abolished if prior to treatment with desmethylimipramine the serotonergic axons were destroyed by an intraventricular injection of 5,7-dihydroxytryptamine. These results show that the down-regulation of β-adrenergic receptors elicited by repeated injections of desmethylimipramine occurs only if the serotonergic axons are intact. © 1982.
1982
21
11
1145
1149
Down-regulation of β-adrenergic receptors following repeated injections of desmethylimipramine: Permissive role of serotonergic axons / Brunello, N.; Barbaccia, M. L.; Chuang, D. -M.; Costa, E.. - In: NEUROPHARMACOLOGY. - ISSN 0028-3908. - 21:11(1982), pp. 1145-1149. [10.1016/0028-3908(82)90172-1]
Brunello, N.; Barbaccia, M. L.; Chuang, D. -M.; Costa, E.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1247739
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