Northern blot analysis using a probe for the low-affinity nerve growth factor receptor (NGFR) revealed that a mild contusive injury induces the expression of NGFR mRNA in rat spinal cord with a maximal expression at 7 days post-injury. We have now localized this induction using in situ hybridization and found the highest concentration of NGFR mRNA at the lesion epicenter. The location and pattern of autoradiographic grains were compared with that of various cell types at the injury site as determined by immunocytochemical studies. The results suggest that cells associated with blood vessels at the epicenter are induced to express NGFR mRNA at 7 days post-injury. © 1991.

Localization of nerve growth factor receptor mRNA in contused rat spinal cord by in situ hybridization / Reynolds, M. E.; Brunello, N.; Mocchetti, I.; Wrathall, J. R.. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 559:1(1991), pp. 149-153. [10.1016/0006-8993(91)90298-A]

Localization of nerve growth factor receptor mRNA in contused rat spinal cord by in situ hybridization

Brunello N.;
1991

Abstract

Northern blot analysis using a probe for the low-affinity nerve growth factor receptor (NGFR) revealed that a mild contusive injury induces the expression of NGFR mRNA in rat spinal cord with a maximal expression at 7 days post-injury. We have now localized this induction using in situ hybridization and found the highest concentration of NGFR mRNA at the lesion epicenter. The location and pattern of autoradiographic grains were compared with that of various cell types at the injury site as determined by immunocytochemical studies. The results suggest that cells associated with blood vessels at the epicenter are induced to express NGFR mRNA at 7 days post-injury. © 1991.
1991
559
1
149
153
Localization of nerve growth factor receptor mRNA in contused rat spinal cord by in situ hybridization / Reynolds, M. E.; Brunello, N.; Mocchetti, I.; Wrathall, J. R.. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 559:1(1991), pp. 149-153. [10.1016/0006-8993(91)90298-A]
Reynolds, M. E.; Brunello, N.; Mocchetti, I.; Wrathall, J. R.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1247737
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 27
  • ???jsp.display-item.citation.isi??? 27
social impact