The discovery by Morris et al. (1994) of the genes contributing to the t(2;5)(p23;q35) translocation has laid the foundation for a molecular based recognition of anaplastic large cell lymphoma and highlighted the need for a further stratification of T-cell neoplasia. Likewise the detection of anaplastic lymphoma kinase (ALK) genetic lesions among many human cancers has defined unique subsets of cancer patients, providing new opportunities for innovative therapeutic interventions. The objective of this review is to appraise the molecular mechanisms driving ALK-mediated transformation, and to maintain the neoplastic phenotype. The understanding of these events will allow the design and implementation of novel tailored strategies for a well-defined subset of cancer patients.
ALK signaling and target therapy in anaplastic large cell lymphoma / F., Tabbó; A., Barreca; R., Piva; G., Inghirami; R., Bruna; D., Corino; D., Cortese; R., Crescenzo; G., Cuccuru; F., Di Giacomo; A., Fioravanti; M., Ladetto; I., Landra; K., Messana; R., Machiorlatti; B., Martinoglio; E., Medico; M., Mossino; E., Pellegrino; M., Todaro; P., Campisi; L., Chiusa; A., Chiappella; D., Novero; U., Vitolo; Abate, Francesco; Acquaviva, Andrea; Ficarra, Elisa; R., Freilone; M., Chilosi; A., Zamó; F., Facchetti; S., Lonardi; A., De Chiara; F., Fulciniti; C., Doglioni; M., Ponzoni; L., Agnelli; A., Neri; K., Todoerti; C., Agostinelli; P. P., Piccaluga; S., Pileri; B., Falini; E., Tiacci; P., Van Loo; T., Tousseyn; C., De Wolf Peeters; E., Geissinger; H. K., Muller Hermelink; A., Rosenwald; M. A., Pirisand; M. E., Rodriguez; F., Bertoni; M., Boi; I., Kwee. - In: FRONTIERS IN ONCOLOGY. - ISSN 2234-943X. - 2:(2012), pp. N/A-N/A. [10.3389/fonc.2012.00041]
ALK signaling and target therapy in anaplastic large cell lymphoma
FICARRA, ELISA;
2012
Abstract
The discovery by Morris et al. (1994) of the genes contributing to the t(2;5)(p23;q35) translocation has laid the foundation for a molecular based recognition of anaplastic large cell lymphoma and highlighted the need for a further stratification of T-cell neoplasia. Likewise the detection of anaplastic lymphoma kinase (ALK) genetic lesions among many human cancers has defined unique subsets of cancer patients, providing new opportunities for innovative therapeutic interventions. The objective of this review is to appraise the molecular mechanisms driving ALK-mediated transformation, and to maintain the neoplastic phenotype. The understanding of these events will allow the design and implementation of novel tailored strategies for a well-defined subset of cancer patients.
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fonc-02-00041.pdf
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