The aim of the study was to evaluate the characteristics of chronic hepatitis B with special reference to the geographical origin of the patients and to the prevalence of HBeAg and viral and non-viral co-factors of liver disease. A cross-sectional multicenter survey was undertaken, which enrolled 1,386 HBsAg chronic carriers observed consecutively in 21 referral centers over a 6-month period. The prevalence of HBeAg in patients was 11%; the presence of HBeAg was associated independently with a younger age and co-infection with HIV. Anti-HDV, anti-HCV, or anti-HIV antibodies were detected in 8.1%, 6.5%, and 2%, respectively. However, among the patients first diagnosed during the study period (incident cases), 14.3% were anti-HDV positive. Seven percent of the patients were immigrants; they were younger than Italian patients and 18% were HBeAg positive; no difference was observed in the prevalence of anti-HDV, anti-HCV, or anti-HIV antibodies. The presence of cirrhosis was associated independently with an age >52 years, the presence of anti-HDV or anti-HCV, alcohol use >4 drinks/day, and a high BMI. The clinical epidemiology of chronic hepatitis B virus (HBV) infection shows a dynamic profile, with the potential for re-emergence of cases with HBeAg or anti-HDV and an emerging impact of metabolic factors on the evolution of liver disease
Evolving clinical landscape of chronic hepatitis B: A multicenter Italian study / Stroffolini, T.; Almasio, P. L.; Sagnelli, E.; Mele, A.; Gaeta, G. B.; Italian Hospitals' Collaborating, Group; Andreone, Pietro; Scuteri, A.; Antonucci, G.; Iacomi, F.; Babudieri, S.; Pintus, A.; Stornaiuolo, G.; Brancaccio, G.; Brunetto, M.; Sasso, R.; Caporaso, N.; Morisco, F.; Chiaramonte, M.; Lattanzi, E.; Di Marco, V.; Venezia, G.; Fagiuoli, S.; Boninsegna, S.; Fattovich, G.; Olivari, N.; Ferrari, C.; Giuberti, T.; Ferrigno, L.; Magnani, G.; Massari, M.; Mangano, C.; Caserta, C.; Messina, V.; Pastore, G.; Palattella, S.; Piccinino, F.; Stanzione, M.; Pinzello, G.; Vinci, M.; Raimondo, G.; Caccamo, G.; Roffi, L.; Bellia, V.; Rizzetto, M.; Smedile, A.; Ciancio, A.. - In: JOURNAL OF MEDICAL VIROLOGY. - ISSN 0146-6615. - 81:12(2009), pp. 1999-2006. [10.1002/jmv.21643]
Evolving clinical landscape of chronic hepatitis B: A multicenter Italian study
ANDREONE, PIETRO;
2009
Abstract
The aim of the study was to evaluate the characteristics of chronic hepatitis B with special reference to the geographical origin of the patients and to the prevalence of HBeAg and viral and non-viral co-factors of liver disease. A cross-sectional multicenter survey was undertaken, which enrolled 1,386 HBsAg chronic carriers observed consecutively in 21 referral centers over a 6-month period. The prevalence of HBeAg in patients was 11%; the presence of HBeAg was associated independently with a younger age and co-infection with HIV. Anti-HDV, anti-HCV, or anti-HIV antibodies were detected in 8.1%, 6.5%, and 2%, respectively. However, among the patients first diagnosed during the study period (incident cases), 14.3% were anti-HDV positive. Seven percent of the patients were immigrants; they were younger than Italian patients and 18% were HBeAg positive; no difference was observed in the prevalence of anti-HDV, anti-HCV, or anti-HIV antibodies. The presence of cirrhosis was associated independently with an age >52 years, the presence of anti-HDV or anti-HCV, alcohol use >4 drinks/day, and a high BMI. The clinical epidemiology of chronic hepatitis B virus (HBV) infection shows a dynamic profile, with the potential for re-emergence of cases with HBeAg or anti-HDV and an emerging impact of metabolic factors on the evolution of liver disease
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