Developmental and epileptic encephalopathies are a group of rare, severe epilepsies, which are characterized by refractory seizures starting in infancy or childhood and developmental delay or regression. Developmental changes might be independent of epilepsy. However, interictal epileptic activity and seizures can further deteriorate cognition and behavior. Recently, the concept of developmental and epileptic encephalopathies has moved from the lesions associated with epileptic encephalopathies toward the epileptic network dysfunctions on the functioning of the brain. Early recognition and differentiation of patients with developmental and epileptic encephalopathies is important, as precision therapies need to be holistic to address the often devastating symptoms. In this review, we discuss the evolution of the concept of developmental and epileptic encephalopathies in recent years, as well as the current understanding of the genetic basis of developmental and epileptic encephalopathies. Finally, we will discuss the role of epileptic network dysfunctions on prognosis for these severe conditions.

Developmental and epileptic encephalopathies: Is prognosis related to different epileptic network dysfunctions? / Lin, J. -J.; Meletti, S.; Vaudano, A. E.; Lin, K. -L.. - In: EPILEPSY & BEHAVIOR. - ISSN 1525-5050. - 131:Pt B(2022), pp. N/A-N/A. [10.1016/j.yebeh.2020.107654]

Developmental and epileptic encephalopathies: Is prognosis related to different epileptic network dysfunctions?

Meletti S.;Vaudano A. E.;
2022

Abstract

Developmental and epileptic encephalopathies are a group of rare, severe epilepsies, which are characterized by refractory seizures starting in infancy or childhood and developmental delay or regression. Developmental changes might be independent of epilepsy. However, interictal epileptic activity and seizures can further deteriorate cognition and behavior. Recently, the concept of developmental and epileptic encephalopathies has moved from the lesions associated with epileptic encephalopathies toward the epileptic network dysfunctions on the functioning of the brain. Early recognition and differentiation of patients with developmental and epileptic encephalopathies is important, as precision therapies need to be holistic to address the often devastating symptoms. In this review, we discuss the evolution of the concept of developmental and epileptic encephalopathies in recent years, as well as the current understanding of the genetic basis of developmental and epileptic encephalopathies. Finally, we will discuss the role of epileptic network dysfunctions on prognosis for these severe conditions.
2022
18-dic-2020
131
Pt B
N/A
N/A
Developmental and epileptic encephalopathies: Is prognosis related to different epileptic network dysfunctions? / Lin, J. -J.; Meletti, S.; Vaudano, A. E.; Lin, K. -L.. - In: EPILEPSY & BEHAVIOR. - ISSN 1525-5050. - 131:Pt B(2022), pp. N/A-N/A. [10.1016/j.yebeh.2020.107654]
Lin, J. -J.; Meletti, S.; Vaudano, A. E.; Lin, K. -L.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1281440
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