A novel mild access to the beta-carboline skeleton is described. The reaction is a Bischler-Napieralski-type cyclocondensation, promoted by (PhO)(3)P center dot Cl-2, which is performed in dichloromethane at -30 degrees C. The products are easily obtained in good yields and do not require further chromatographic purification.
A novel mild access to the β-carboline skeleton is described. The reaction is a Bischler-Napieralski-type cyclocondensation, promoted by (PhO)3P·Cl2, which is performed in dichloromethane at -30 °C. The products are easily obtained in good yields and do not require further chromatographic purification.
(PhO)3P·Cl2-promoted bischler-napieralski-type cyclization: A mild access to β-carbolines / Spaggiari, A.; Davoli, P.; Blaszczak, L. C.; Prati, F.. - In: SYNLETT. - ISSN 0936-5214. - STAMPA. - 4:4(2005), pp. 661-663. [10.1055/s-2005-862394]
(PhO)3P·Cl2-promoted bischler-napieralski-type cyclization: A mild access to β-carbolines
Spaggiari A.;Davoli P.;Prati F.
2005
Abstract
A novel mild access to the β-carboline skeleton is described. The reaction is a Bischler-Napieralski-type cyclocondensation, promoted by (PhO)3P·Cl2, which is performed in dichloromethane at -30 °C. The products are easily obtained in good yields and do not require further chromatographic purification.
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