Growing interest is recently being focused on the role played by the platelets in favoring hepatocellular cancer (HCC) growth and dissemination. The present review reports in detail both the experimental and clinical evidence published on this topic. Several growth factors and angiogenic molecules specifically secreted by platelets are directly connected with tumor progression and neo-angiogenesis. Among them, we can list the platelet-derived growth factor, the vascular endothelial growth factor, the endothelial growth factor, and serotonin. Platelets are also involved in tumor spread, favoring endothelium permeabilization and tumor cells' extravasation and survival in the bloodstream. From the bench to the clinics, all of these aspects were also investigated in clinical series, showing an evident correlation between platelet count and size of HCC, tumor biological behavior, metastatic spread, and overall survival rates. Moreover, a better understanding of the mechanisms involved in the platelet-tumor axis represents a paramount aspect for optimizing both current tumor treatment and development of new therapeutic strategies against HCC.

Platelets and Hepatocellular Cancer: Bridging the Bench to the Clinics / Lai, ; Q., aEmail Author; Vitale, ; A., bEmail Author; Manzia, ; T. M., cEmail Author; Foschi, ; F. G., dEmail Author; Sandri, ; G. B. L., eEmail Author; Gambato, ; M., bEmail Author; Melandro, ; F., fEmail Author; Russo, ; F. P., bEmail Author; Miele, ; L., gEmail Author; Viganò, ; L., hEmail Author; Burra, ; P., bEmail Author; Giannini, ; E. G., iEmail Author; Aliberti, C.; Baccarani, U.; Bhoori, S.; Borzio, M.; Brancaccio, G.; Cabibbo, G.; Casadei, Gardini; A., Carrai; P., Cillo; U., Conti; F., Cucchetti; A., D’Ambrosio; R., Dell’Unto; C., Dematthaeis; Di, Costanzo; G., G.; Di Sandro, S.; Fucilli, F.; Galati, G.; Gasbarrini, A.; Giuliante, F.; Ghinolfi, D.; Grieco, A.; Gruttaduria, S.; Guarino, M.; Kostandini, A.; Iavarone, M.; Lenci, I.; Losito, F.; Lupo, L. G.; Mazzocato, S.; Mescoli, C.; Miele, L.; Morisco, F.; Muley, M.; Nicolini, D.; Persico, M.; Pompili, M.; Ponziani, F. R.; Pravisani, R.; Rapaccini, G. L.; Rendina, M.; Renzulli, M.; Rossi, M.; Rreka, E.; Sacco, R.; Sangiovanni, A.; Sessa, A.; Simonetti, N.; Sposito, C.; Tortora, R.; Trevisani, F.; Viganò, M.; Villa, E.; Vincenzi, V.; Violi, P.; Associazione Italiana per lo Studio del Fegato (AISF) HCC Special Interest, Group. - In: CANCERS. - ISSN 2072-6694. - 11:10(2019), pp. 1568-1568. [10.3390/cancers11101568]

Platelets and Hepatocellular Cancer: Bridging the Bench to the Clinics

Casadei Gardini;Di Sandro S.;Villa E.;
2019

Abstract

Growing interest is recently being focused on the role played by the platelets in favoring hepatocellular cancer (HCC) growth and dissemination. The present review reports in detail both the experimental and clinical evidence published on this topic. Several growth factors and angiogenic molecules specifically secreted by platelets are directly connected with tumor progression and neo-angiogenesis. Among them, we can list the platelet-derived growth factor, the vascular endothelial growth factor, the endothelial growth factor, and serotonin. Platelets are also involved in tumor spread, favoring endothelium permeabilization and tumor cells' extravasation and survival in the bloodstream. From the bench to the clinics, all of these aspects were also investigated in clinical series, showing an evident correlation between platelet count and size of HCC, tumor biological behavior, metastatic spread, and overall survival rates. Moreover, a better understanding of the mechanisms involved in the platelet-tumor axis represents a paramount aspect for optimizing both current tumor treatment and development of new therapeutic strategies against HCC.
2019
11
10
1568
1568
Platelets and Hepatocellular Cancer: Bridging the Bench to the Clinics / Lai, ; Q., aEmail Author; Vitale, ; A., bEmail Author; Manzia, ; T. M., cEmail Author; Foschi, ; F. G., dEmail Author; Sandri, ; G. B. L., eEmail Author; Gambato, ; M., bEmail Author; Melandro, ; F., fEmail Author; Russo, ; F. P., bEmail Author; Miele, ; L., gEmail Author; Viganò, ; L., hEmail Author; Burra, ; P., bEmail Author; Giannini, ; E. G., iEmail Author; Aliberti, C.; Baccarani, U.; Bhoori, S.; Borzio, M.; Brancaccio, G.; Cabibbo, G.; Casadei, Gardini; A., Carrai; P., Cillo; U., Conti; F., Cucchetti; A., D’Ambrosio; R., Dell’Unto; C., Dematthaeis; Di, Costanzo; G., G.; Di Sandro, S.; Fucilli, F.; Galati, G.; Gasbarrini, A.; Giuliante, F.; Ghinolfi, D.; Grieco, A.; Gruttaduria, S.; Guarino, M.; Kostandini, A.; Iavarone, M.; Lenci, I.; Losito, F.; Lupo, L. G.; Mazzocato, S.; Mescoli, C.; Miele, L.; Morisco, F.; Muley, M.; Nicolini, D.; Persico, M.; Pompili, M.; Ponziani, F. R.; Pravisani, R.; Rapaccini, G. L.; Rendina, M.; Renzulli, M.; Rossi, M.; Rreka, E.; Sacco, R.; Sangiovanni, A.; Sessa, A.; Simonetti, N.; Sposito, C.; Tortora, R.; Trevisani, F.; Viganò, M.; Villa, E.; Vincenzi, V.; Violi, P.; Associazione Italiana per lo Studio del Fegato (AISF) HCC Special Interest, Group. - In: CANCERS. - ISSN 2072-6694. - 11:10(2019), pp. 1568-1568. [10.3390/cancers11101568]
Lai, ; Q., aEmail Author; Vitale, ; A., bEmail Author; Manzia, ; T. M., cEmail Author; Foschi, ; F. G., dEmail Author; Sandri, ; G. B. L., eEmail Author; Gambato, ; M., bEmail Author; Melandro, ; F., fEmail Author; Russo, ; F. P., bEmail Author; Miele, ; L., gEmail Author; Viganò, ; L., hEmail Author; Burra, ; P., bEmail Author; Giannini, ; E. G., iEmail Author; Aliberti, C.; Baccarani, U.; Bhoori, S.; Borzio, M.; Brancaccio, G.; Cabibbo, G.; Casadei, Gardini; A., Carrai; P., Cillo; U., Conti; F., Cucchetti; A., D’Ambrosio; R., Dell’Unto; C., Dematthaeis; Di, Costanzo; G., G.; Di Sandro, S.; Fucilli, F.; Galati, G.; Gasbarrini, A.; Giuliante, F.; Ghinolfi, D.; Grieco, A.; Gruttaduria, S.; Guarino, M.; Kostandini, A.; Iavarone, M.; Lenci, I.; Losito, F.; Lupo, L. G.; Mazzocato, S.; Mescoli, C.; Miele, L.; Morisco, F.; Muley, M.; Nicolini, D.; Persico, M.; Pompili, M.; Ponziani, F. R.; Pravisani, R.; Rapaccini, G. L.; Rendina, M.; Renzulli, M.; Rossi, M.; Rreka, E.; Sacco, R.; Sangiovanni, A.; Sessa, A.; Simonetti, N.; Sposito, C.; Tortora, R.; Trevisani, F.; Viganò, M.; Villa, E.; Vincenzi, V.; Violi, P.; Associazione Italiana per lo Studio del Fegato (AISF) HCC Special Interest, Group
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