Myosin ATPase activity was measured, by continuous luminometric method, in presence of different molecular weight heparins. ATPase activity decreases in thè presence of heparin, when simultaneous incubation with ATP is carried out; thè percentage of inhibition is proportional to polysaccharide concentration. Heparins of different molecular weights (1.75 KD to 11.6 KD) are competitive inhibitors of enzymatìc activity; thè inhibitory effects is also appreciable with trisulphated disaccharide.The possible mechanisms of interactìon between heparin and myosin ATPase are discussed.
COMPETITIVE-INHIBITION OF MYOSIN ATPASE ACTIVITY BY DIFFERENT MOLECULAR-WEIGHT HEPARINS / Volpi, Nicola; Bianchini, P; Bolognani, L.. - In: BIOCHEMISTRY INTERNATIONAL. - ISSN 0158-5231. - STAMPA. - 24:(1991), pp. 243-253.
COMPETITIVE-INHIBITION OF MYOSIN ATPASE ACTIVITY BY DIFFERENT MOLECULAR-WEIGHT HEPARINS
VOLPI, Nicola;
1991
Abstract
Myosin ATPase activity was measured, by continuous luminometric method, in presence of different molecular weight heparins. ATPase activity decreases in thè presence of heparin, when simultaneous incubation with ATP is carried out; thè percentage of inhibition is proportional to polysaccharide concentration. Heparins of different molecular weights (1.75 KD to 11.6 KD) are competitive inhibitors of enzymatìc activity; thè inhibitory effects is also appreciable with trisulphated disaccharide.The possible mechanisms of interactìon between heparin and myosin ATPase are discussed.
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