To assess the relationship between cell proliferation and cell death, the mRNA accumulation of ornithine decarboxylase (ODC)and sulfated glycoprotein 2 (SGP-2) were measured in human peripheral blood lymphocytes (HPBL), 2-6 hours after stimulation with phytohemoagglutinin (PHA). A consistent amount of SGP-2 mRNA in quiescent HPBL, an early and progressive decrease of SGP-2 mRNA and a parallel increase of ODC mRNA accumulation, were observed, in PHA-stimulated HPBL, suggesting that concomitant repression of SGP-2 and induction of ODC genes contribute for the cell entering the cell cycle.
STUDIES ON THE RELATIONSHIP BETWEEN CELL-PROLIFERATION AND CELL-DEATH - OPPOSITE PATTERNS OF SGP-2 AND ORNITHINE DECARBOXYLASE MESSENGER-RNA ACCUMULATION IN PHA-STIMULATED HUMAN-LYMPHOCYTES / Grassilli, E; Bettuzzi, S; Monti, D; Ingletti, Mc; Franceschi, C; Corti, Arnaldo. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - STAMPA. - 180:(1991), pp. 59-63.
STUDIES ON THE RELATIONSHIP BETWEEN CELL-PROLIFERATION AND CELL-DEATH - OPPOSITE PATTERNS OF SGP-2 AND ORNITHINE DECARBOXYLASE MESSENGER-RNA ACCUMULATION IN PHA-STIMULATED HUMAN-LYMPHOCYTES
CORTI, Arnaldo
1991
Abstract
To assess the relationship between cell proliferation and cell death, the mRNA accumulation of ornithine decarboxylase (ODC)and sulfated glycoprotein 2 (SGP-2) were measured in human peripheral blood lymphocytes (HPBL), 2-6 hours after stimulation with phytohemoagglutinin (PHA). A consistent amount of SGP-2 mRNA in quiescent HPBL, an early and progressive decrease of SGP-2 mRNA and a parallel increase of ODC mRNA accumulation, were observed, in PHA-stimulated HPBL, suggesting that concomitant repression of SGP-2 and induction of ODC genes contribute for the cell entering the cell cycle.
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