We recently described the presence of 3 pilus variants in the human pathogen group B streptococcus (GBS; also known as Streptococcus agalactiae), each encoded by a distinct pathogenicity island, as well as the ability of pilus components to elicit protection in mice against homologous challenge. To determine whether a vaccine containing a combination of proteins from the 3 pilus types could provide broad protection, we analyzed pili distribution and conservation in 289 clinical isolates. We found that pilus sequences in each island are conserved, all strains carried at least 1 of the 3 islands, and a combination of the 3 pilus components conferred protection against all tested GBS challenge strains. These data are the first to indicate that a vaccine exclusively constituted by pilus components can be effective in preventing infections caused by GBS, and they pave the way for the use of a similar approach against other pathogenic streptococci. © 2008 by the Infectious Diseases Society of America. All rights reserved.

Preventing bacterial infections with pilus-based vaccines: The group B streptococcus paradigm / Margarit, Immaculada; Rinaudo, Cira Daniela; Galeotti, Cesira L.; Maione, Domenico; Ghezzo, Claudia; Buttazzoni, Elena; Rosini, Roberto; Runci, Ylenia; Mora, Marirosa; Buccato, Scilla; Pagani, Massimiliano; Tresoldi, Eleonora; Berardi, Alberto; Creti, Roberta; Baker, Carol J.; Telford, John L.; Grandi, Guido. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - 199:1(2009), pp. 108-115. [10.1086/595564]

Preventing bacterial infections with pilus-based vaccines: The group B streptococcus paradigm

Berardi, Alberto;
2009

Abstract

We recently described the presence of 3 pilus variants in the human pathogen group B streptococcus (GBS; also known as Streptococcus agalactiae), each encoded by a distinct pathogenicity island, as well as the ability of pilus components to elicit protection in mice against homologous challenge. To determine whether a vaccine containing a combination of proteins from the 3 pilus types could provide broad protection, we analyzed pili distribution and conservation in 289 clinical isolates. We found that pilus sequences in each island are conserved, all strains carried at least 1 of the 3 islands, and a combination of the 3 pilus components conferred protection against all tested GBS challenge strains. These data are the first to indicate that a vaccine exclusively constituted by pilus components can be effective in preventing infections caused by GBS, and they pave the way for the use of a similar approach against other pathogenic streptococci. © 2008 by the Infectious Diseases Society of America. All rights reserved.
2009
199
1
108
115
Preventing bacterial infections with pilus-based vaccines: The group B streptococcus paradigm / Margarit, Immaculada; Rinaudo, Cira Daniela; Galeotti, Cesira L.; Maione, Domenico; Ghezzo, Claudia; Buttazzoni, Elena; Rosini, Roberto; Runci, Ylenia; Mora, Marirosa; Buccato, Scilla; Pagani, Massimiliano; Tresoldi, Eleonora; Berardi, Alberto; Creti, Roberta; Baker, Carol J.; Telford, John L.; Grandi, Guido. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - 199:1(2009), pp. 108-115. [10.1086/595564]
Margarit, Immaculada; Rinaudo, Cira Daniela; Galeotti, Cesira L.; Maione, Domenico; Ghezzo, Claudia; Buttazzoni, Elena; Rosini, Roberto; Runci, Ylenia; Mora, Marirosa; Buccato, Scilla; Pagani, Massimiliano; Tresoldi, Eleonora; Berardi, Alberto; Creti, Roberta; Baker, Carol J.; Telford, John L.; Grandi, Guido
File in questo prodotto:
File Dimensione Formato  
Margarit_Pilus_2009.pdf

Accesso riservato

Descrizione: Articolo principale
Tipologia: Versione pubblicata dall'editore
Dimensione 352.22 kB
Formato Adobe PDF
352.22 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1168709
Citazioni
  • ???jsp.display-item.citation.pmc??? 79
  • Scopus 189
  • ???jsp.display-item.citation.isi??? 173
social impact