Photoreceptor cell death in inherited retinal degeneration is accompanied by over-activation of histone deacetylases (HDAC). Excessive HDAC activity is found both in primary rod degeneration (such as in the rd10 mouse) and in primary cone death, including the cone photoreceptor function loss 1 (cpfl1) mouse. We evaluated the potential of pharmacological HDAC inhibition to prevent photoreceptor degeneration in primary rod and cone degeneration. We show that a single in vivo treatment of cpfl1 mice with the HDAC inhibitor trichostatin A (TSA) resulted in a significant protection of cpfl1 mutant cones. Similarly, HDAC inhibition with the clinically approved HDAC inhibitor vorinostat (SAHA) resulted in a significant improvement of rod survival in rd10 retinal explant cultures. Altogether, these results highlight the feasibility of targeted neuroprotection in vivo and create hope to maintain vision in patients suffering from both rod and cone dystrophies.

Primary rod and cone degeneration is prevented by HDAC inhibition / Trifunović, Dragana; Petridou, Eleni; Comitato, Antonella; Marigo, Valeria; Ueffing, Marius; Paquet-Durand, François. - 1074:(2018), pp. 367-373. (Intervento presentato al convegno 17th International Symposium on Retinal Degeneration (RD) tenutosi a Kyoto, JAPAN nel SEP 19-24, 2016) [10.1007/978-3-319-75402-4_45].

Primary rod and cone degeneration is prevented by HDAC inhibition

Comitato, Antonella
Data Curation
;
Marigo, Valeria
Writing – Review & Editing
;
2018

Abstract

Photoreceptor cell death in inherited retinal degeneration is accompanied by over-activation of histone deacetylases (HDAC). Excessive HDAC activity is found both in primary rod degeneration (such as in the rd10 mouse) and in primary cone death, including the cone photoreceptor function loss 1 (cpfl1) mouse. We evaluated the potential of pharmacological HDAC inhibition to prevent photoreceptor degeneration in primary rod and cone degeneration. We show that a single in vivo treatment of cpfl1 mice with the HDAC inhibitor trichostatin A (TSA) resulted in a significant protection of cpfl1 mutant cones. Similarly, HDAC inhibition with the clinically approved HDAC inhibitor vorinostat (SAHA) resulted in a significant improvement of rod survival in rd10 retinal explant cultures. Altogether, these results highlight the feasibility of targeted neuroprotection in vivo and create hope to maintain vision in patients suffering from both rod and cone dystrophies.
2018
RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY
978-3-319-75402-4
978-3-319-75401-7
SPRINGER INTERNATIONAL PUBLISHING AG
STATI UNITI D'AMERICA
Primary rod and cone degeneration is prevented by HDAC inhibition / Trifunović, Dragana; Petridou, Eleni; Comitato, Antonella; Marigo, Valeria; Ueffing, Marius; Paquet-Durand, François. - 1074:(2018), pp. 367-373. (Intervento presentato al convegno 17th International Symposium on Retinal Degeneration (RD) tenutosi a Kyoto, JAPAN nel SEP 19-24, 2016) [10.1007/978-3-319-75402-4_45].
Trifunović, Dragana; Petridou, Eleni; Comitato, Antonella; Marigo, Valeria; Ueffing, Marius; Paquet-Durand, François
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1162510
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