Introduction: With improvements in assays and the increasing need for non-invasive, out-patient based investigations, there is a renewed interest in the use of urinary gonadotrophins (UG) for assessing pubertal progress. This study aims to establish the correlation between serum and urinary LH and FSH in patients undergoing investigation or management of pubertal disorders. Methods/design: Retrospective evaluation of eight patients undergoing investigation for pubertal delay (five males and three females) and 21 patients (six males and 15 females) for early puberty or suppression of puberty by GnRH agonist (GnRH-a) therapy. Median ages (range) for the boys and girls were 14.4 years (8.9–17.2) and 9.2 years (4.2–17.3), respectively. Non-timed spot urine samples were collected for all cases and 11 (five males and six females) of these were on GnRH-a. Of the 29 cases, matched serum gonadotrophins were available in 15 cases (seven males and eight females). UG were measured by chemiluminescent microparticle immunoassay and corrected for urinary creatinine. Results: In both pubertal males and females, UG were significantly higher than during-GnRH-a treatment: For the 15 cases with matched serum and urine samples, median serum LH and ULH:creat were 1.5 U/l (0.1–21.9) and 0.16 (0–1.37), respectively. There was a strong correlation between these values (r2, 0.92), independent of sex. Conclusion: These preliminary data suggest that UG reflect serum gonadotrophin concentrations and the finding of low UG in patients on GnRH-a therapy suggest that this test may represent a useful non-invasive method of assessing and monitoring effectiveness of GnRH-a therapy.

Urinary gonadotrophins: role in assessment and management of disorders of puberty / Lucaccioni, Laura; Jane, D McNeilly; Avril, Mason; M Guftar, Shaikh; Claudio, Giacomozzi; S Faisal, Ahmed. - In: ENDOCRINOLOGY ABSTRACTS. - ISSN 1470-3947. - (2013). [10.1530/endoabs.33.P77]

Urinary gonadotrophins: role in assessment and management of disorders of puberty

Lucaccioni Laura;
2013

Abstract

Introduction: With improvements in assays and the increasing need for non-invasive, out-patient based investigations, there is a renewed interest in the use of urinary gonadotrophins (UG) for assessing pubertal progress. This study aims to establish the correlation between serum and urinary LH and FSH in patients undergoing investigation or management of pubertal disorders. Methods/design: Retrospective evaluation of eight patients undergoing investigation for pubertal delay (five males and three females) and 21 patients (six males and 15 females) for early puberty or suppression of puberty by GnRH agonist (GnRH-a) therapy. Median ages (range) for the boys and girls were 14.4 years (8.9–17.2) and 9.2 years (4.2–17.3), respectively. Non-timed spot urine samples were collected for all cases and 11 (five males and six females) of these were on GnRH-a. Of the 29 cases, matched serum gonadotrophins were available in 15 cases (seven males and eight females). UG were measured by chemiluminescent microparticle immunoassay and corrected for urinary creatinine. Results: In both pubertal males and females, UG were significantly higher than during-GnRH-a treatment: For the 15 cases with matched serum and urine samples, median serum LH and ULH:creat were 1.5 U/l (0.1–21.9) and 0.16 (0–1.37), respectively. There was a strong correlation between these values (r2, 0.92), independent of sex. Conclusion: These preliminary data suggest that UG reflect serum gonadotrophin concentrations and the finding of low UG in patients on GnRH-a therapy suggest that this test may represent a useful non-invasive method of assessing and monitoring effectiveness of GnRH-a therapy.
2013
Lucaccioni, Laura; Jane, D McNeilly; Avril, Mason; M Guftar, Shaikh; Claudio, Giacomozzi; S Faisal, Ahmed
Urinary gonadotrophins: role in assessment and management of disorders of puberty / Lucaccioni, Laura; Jane, D McNeilly; Avril, Mason; M Guftar, Shaikh; Claudio, Giacomozzi; S Faisal, Ahmed. - In: ENDOCRINOLOGY ABSTRACTS. - ISSN 1470-3947. - (2013). [10.1530/endoabs.33.P77]
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1157095
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact