Several large cohort studies have disclosed the trajectories of sex steroids changes overtime in men and their clinical significance. In men the slow, physiological decline of serum testosterone (T) with advancing age overlaps with the clinical condition of overt, pathological hypogonadism. In addition, the increasing number of comorbidities, together with the high prevalence of chronic diseases, all further contribute to the decrease of serum T concentrations in the aging male. For all these reasons both the diagnosis of late-onset hypogonadism (LOH) in men and the decision about starting or not T replacement treatment remain challenging. At present, the biochemical finding of T deficiency alone is not sufficient for diagnosing hypogonadism in older men. Coupling hypogonadal symptoms with documented low serum T represents the best strategy to refine the diagnosis of hypogonadism in older men and to avoid unnecessary treatments.

Aging and sex hormones in males / Decaroli, Maria Chiara; Rochira, Vincenzo. - In: VIRULENCE. - ISSN 2150-5594. - 8:5(2017), pp. 545-570. [10.1080/21505594.2016.1259053]

Aging and sex hormones in males

DECAROLI, MARIA CHIARA;ROCHIRA, Vincenzo
2017

Abstract

Several large cohort studies have disclosed the trajectories of sex steroids changes overtime in men and their clinical significance. In men the slow, physiological decline of serum testosterone (T) with advancing age overlaps with the clinical condition of overt, pathological hypogonadism. In addition, the increasing number of comorbidities, together with the high prevalence of chronic diseases, all further contribute to the decrease of serum T concentrations in the aging male. For all these reasons both the diagnosis of late-onset hypogonadism (LOH) in men and the decision about starting or not T replacement treatment remain challenging. At present, the biochemical finding of T deficiency alone is not sufficient for diagnosing hypogonadism in older men. Coupling hypogonadal symptoms with documented low serum T represents the best strategy to refine the diagnosis of hypogonadism in older men and to avoid unnecessary treatments.
2017
10-nov-2016
8
5
545
570
Aging and sex hormones in males / Decaroli, Maria Chiara; Rochira, Vincenzo. - In: VIRULENCE. - ISSN 2150-5594. - 8:5(2017), pp. 545-570. [10.1080/21505594.2016.1259053]
Decaroli, Maria Chiara; Rochira, Vincenzo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1142090
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