Background The management of basal cell carcinoma (BCC) depends, among other factors, on its histopathologic subtype. Although dermoscopic criteria of BCC have been investigated, the possible role of dermoscopy in predicting the tumor subtype remains unclear. Objectives We sought to assess the diagnostic accuracy of dermoscopic criteria for differentiating superficial BCC (sBCC) from other BCC subtypes. Methods Dermoscopic images of histopathologically confirmed BCCs were retrospectively evaluated for the presence of predefined criteria. Univariate and adjusted odds ratios were calculated. Discriminant functions were used to plot receiver operating characteristic curves. Results In all, 77 sBCCs and 258 non-sBCCs were included. Maple leaf-like areas, short fine superficial telangiectasia, multiple small erosions, and shiny white-red structureless areas were potent predictors of sBCC, each making its diagnosis over 5-fold more likely. Conversely, the presence of arborizing vessels, blue-gray ovoid nests, and ulceration gave 11-fold, 15-fold, and 3-fold increased possibility for the diagnosis of non-sBCCs, respectively. Based on the results of the multivariate analysis, we propose a diagnostic algorithm that can predict the diagnosis of sBCC with a sensitivity of 81.9% and a specificity of 81.8%. Limitations The retrospective design and the inclusion of only Caucasian patients are limitations. Conclusion Dermoscopy is reliable in differentiating sBCC from other BCC subtypes. © 2013 by the American Academy of Dermatology, Inc.

Accuracy of dermoscopic criteria for discriminating superficial from other subtypes of basal cell carcinoma / Lallas, Aimilios; Tzellos, Thrassivoulos; Kyrgidis, Athanasios; Apalla, Zoe; Zalaudek, Iris; Karatolias, Athanasios; Ferrara, Gerardo; Piana, Simonetta; Longo, Caterina; Moscarella, Elvira; Stratigos, Alexander; Argenziano, Giuseppe. - In: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. - ISSN 0190-9622. - 70:2(2014), pp. 303-311. [10.1016/j.jaad.2013.10.003]

Accuracy of dermoscopic criteria for discriminating superficial from other subtypes of basal cell carcinoma

LONGO, Caterina;MOSCARELLA, ELVIRA;ARGENZIANO, GIUSEPPE
2014

Abstract

Background The management of basal cell carcinoma (BCC) depends, among other factors, on its histopathologic subtype. Although dermoscopic criteria of BCC have been investigated, the possible role of dermoscopy in predicting the tumor subtype remains unclear. Objectives We sought to assess the diagnostic accuracy of dermoscopic criteria for differentiating superficial BCC (sBCC) from other BCC subtypes. Methods Dermoscopic images of histopathologically confirmed BCCs were retrospectively evaluated for the presence of predefined criteria. Univariate and adjusted odds ratios were calculated. Discriminant functions were used to plot receiver operating characteristic curves. Results In all, 77 sBCCs and 258 non-sBCCs were included. Maple leaf-like areas, short fine superficial telangiectasia, multiple small erosions, and shiny white-red structureless areas were potent predictors of sBCC, each making its diagnosis over 5-fold more likely. Conversely, the presence of arborizing vessels, blue-gray ovoid nests, and ulceration gave 11-fold, 15-fold, and 3-fold increased possibility for the diagnosis of non-sBCCs, respectively. Based on the results of the multivariate analysis, we propose a diagnostic algorithm that can predict the diagnosis of sBCC with a sensitivity of 81.9% and a specificity of 81.8%. Limitations The retrospective design and the inclusion of only Caucasian patients are limitations. Conclusion Dermoscopy is reliable in differentiating sBCC from other BCC subtypes. © 2013 by the American Academy of Dermatology, Inc.
2014
70
2
303
311
Accuracy of dermoscopic criteria for discriminating superficial from other subtypes of basal cell carcinoma / Lallas, Aimilios; Tzellos, Thrassivoulos; Kyrgidis, Athanasios; Apalla, Zoe; Zalaudek, Iris; Karatolias, Athanasios; Ferrara, Gerardo; Piana, Simonetta; Longo, Caterina; Moscarella, Elvira; Stratigos, Alexander; Argenziano, Giuseppe. - In: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. - ISSN 0190-9622. - 70:2(2014), pp. 303-311. [10.1016/j.jaad.2013.10.003]
Lallas, Aimilios; Tzellos, Thrassivoulos; Kyrgidis, Athanasios; Apalla, Zoe; Zalaudek, Iris; Karatolias, Athanasios; Ferrara, Gerardo; Piana, Simonetta; Longo, Caterina; Moscarella, Elvira; Stratigos, Alexander; Argenziano, Giuseppe
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1140845
Citazioni
  • ???jsp.display-item.citation.pmc??? 27
  • Scopus 118
  • ???jsp.display-item.citation.isi??? 97
social impact