Alterations of the cardiac autonomic nervous system play an important role in the pathway of many heart diseases. Nuclear imaging tools have been demonstrated to be useful for global and regional assessment of myocardial innervation. We used (11)C-meta-hydroxy-ephedrine ((11)C-mHED), a catecholamine analogue, as a radiotracer usable with a PET/CT scanner to study the cardiac sympathetic system. After a fast and automatic synthesis of mHED and its labeling with (11)C, we acquired cardiac images by using a PET/ CT scanner. In this paper we present our preliminary results showing the radiotracer bio-distribution in humans 10 minutes post injection. The present study assesses the feasibility of PET/CT with the radiolabeled catecholamine analogue ((11)C-mHED) in order to determine sympathetic innervation in the human heart.

11C-mHED for PET / CT: principles of synthesis, methodology and first clinical applications / Bonfiglioli, Rachele; Nanni, Cristina; Martignani, Cristian; Zanoni, Lucia; La Donna, Raffaele; Diemberger, Igor; Boriani, Giuseppe; Pettinato, Cinzia; Sambuceti, Gianmario; Fanti, Stefano; Mansi, Luigi. - In: CURRENT RADIOPHARMACEUTICALS. - ISSN 1874-4710. - 7:2(2014), pp. 79-83. [10.2174/1874471007666140714111304]

11C-mHED for PET / CT: principles of synthesis, methodology and first clinical applications

BORIANI, Giuseppe;
2014

Abstract

Alterations of the cardiac autonomic nervous system play an important role in the pathway of many heart diseases. Nuclear imaging tools have been demonstrated to be useful for global and regional assessment of myocardial innervation. We used (11)C-meta-hydroxy-ephedrine ((11)C-mHED), a catecholamine analogue, as a radiotracer usable with a PET/CT scanner to study the cardiac sympathetic system. After a fast and automatic synthesis of mHED and its labeling with (11)C, we acquired cardiac images by using a PET/ CT scanner. In this paper we present our preliminary results showing the radiotracer bio-distribution in humans 10 minutes post injection. The present study assesses the feasibility of PET/CT with the radiolabeled catecholamine analogue ((11)C-mHED) in order to determine sympathetic innervation in the human heart.
2014
7
2
79
83
11C-mHED for PET / CT: principles of synthesis, methodology and first clinical applications / Bonfiglioli, Rachele; Nanni, Cristina; Martignani, Cristian; Zanoni, Lucia; La Donna, Raffaele; Diemberger, Igor; Boriani, Giuseppe; Pettinato, Cinzia; Sambuceti, Gianmario; Fanti, Stefano; Mansi, Luigi. - In: CURRENT RADIOPHARMACEUTICALS. - ISSN 1874-4710. - 7:2(2014), pp. 79-83. [10.2174/1874471007666140714111304]
Bonfiglioli, Rachele; Nanni, Cristina; Martignani, Cristian; Zanoni, Lucia; La Donna, Raffaele; Diemberger, Igor; Boriani, Giuseppe; Pettinato, Cinzia; Sambuceti, Gianmario; Fanti, Stefano; Mansi, Luigi
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1139657
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 5
  • ???jsp.display-item.citation.isi??? ND
social impact