Several classes of recreational and prescription drugs have additional effects on the heart and vasculature, which may significantly contribute to morbidity and mortality in chronic users. The study presented herein focuses on pathological changes involving the heart possibly due to anabolic androgenic steroid use. The role these hormones may play in their occurrence of sudden cardiac death is also investigated. 98 medico-legal cases including 6 anabolic androgenic steroid users were retrospectively reviewed. Autopsies, histology, immunohistochemistry, biochemistry and toxicology were performed in all cases. Pathological changes consisted of various degrees of interstitial and perivascular fibrosis as well as fibroadipous metaplasia and perineural fibrosis within the myocardium of the left ventricle. Within the limits of the small number of investigated cases, our results appear to confirm former observations on this topic and suggest anabolic androgenic steroid's potential causative role in the pathogenesis of sudden cardiac deaths in chronic users

Pathological changes in anabolic androgenic steroid users / Lusetti, M; Licata, Manuela; Silingardi, Enrico; Reggiani Bonetti, L; Palmiere, C.. - In: JOURNAL OF FORENSIC AND LEGAL MEDICINE. - ISSN 1752-928X. - 33:(2015), pp. 101-104. [10.1016/j.jflm.2015.04.014]

Pathological changes in anabolic androgenic steroid users

Lusetti, M;LICATA, Manuela;SILINGARDI, Enrico;
2015

Abstract

Several classes of recreational and prescription drugs have additional effects on the heart and vasculature, which may significantly contribute to morbidity and mortality in chronic users. The study presented herein focuses on pathological changes involving the heart possibly due to anabolic androgenic steroid use. The role these hormones may play in their occurrence of sudden cardiac death is also investigated. 98 medico-legal cases including 6 anabolic androgenic steroid users were retrospectively reviewed. Autopsies, histology, immunohistochemistry, biochemistry and toxicology were performed in all cases. Pathological changes consisted of various degrees of interstitial and perivascular fibrosis as well as fibroadipous metaplasia and perineural fibrosis within the myocardium of the left ventricle. Within the limits of the small number of investigated cases, our results appear to confirm former observations on this topic and suggest anabolic androgenic steroid's potential causative role in the pathogenesis of sudden cardiac deaths in chronic users
2015
5-mag-2015
33
101
104
Pathological changes in anabolic androgenic steroid users / Lusetti, M; Licata, Manuela; Silingardi, Enrico; Reggiani Bonetti, L; Palmiere, C.. - In: JOURNAL OF FORENSIC AND LEGAL MEDICINE. - ISSN 1752-928X. - 33:(2015), pp. 101-104. [10.1016/j.jflm.2015.04.014]
Lusetti, M; Licata, Manuela; Silingardi, Enrico; Reggiani Bonetti, L; Palmiere, C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1138017
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