A study into the use of a chiral phase-transfer catalyst in conjunction with acetone cyanohydrin to effect the enantioselective formation of alpha-amino nitriles from alpha-amido sulfones is described. This novel catalytic asymmetric Strecker reaction is analyzed with regard to the possible mechanistic basis.
Phase Transfer Catalyzed Enantioselective Strecker Reactions of alpha-Amido Sulfones with Cyanoydrins / Herrera, Raquel P.; Sgarzani, Valentina; Bernardi, Luca; Fini, Francesco; Pettersen, Daniel; Ricci, Alfredo. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - STAMPA. - 71:26(2006), pp. 9869-9872. [10.1021/jo061566u]
Phase Transfer Catalyzed Enantioselective Strecker Reactions of alpha-Amido Sulfones with Cyanoydrins
FINI, Francesco;
2006
Abstract
A study into the use of a chiral phase-transfer catalyst in conjunction with acetone cyanohydrin to effect the enantioselective formation of alpha-amino nitriles from alpha-amido sulfones is described. This novel catalytic asymmetric Strecker reaction is analyzed with regard to the possible mechanistic basis.
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