Synthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia furfur, including caspofungin and triazole resistant strains. Alanine-substituted derivatives of fungicidal Fc-peptides, tested to evaluate the critical role of each residue, displayed unaltered, increased or decreased candidacidal activity in vitro. An Fc-peptide, included in all human IgGs, displayed a therapeutic effect against experimental mucosal and systemic candidiasis in mouse models. It is intriguing to hypothesize that some Fc-peptides may influence the antifungal immune response and constitute the basis for devising new antifungal agents.

Peptides of the constant region of antibodies display fungicidal activity / Polonelli, L; Ciociola, T; Magliani, W; Zanello, Pp; D'Adda, T; Galati, S; De Bernardis, F; Arancia, S; Gabrielli, E; Pericolini, Eva; Vecchiarelli, A; Arruda, Dc; Pinto, Mr; Travassos, Lr; Pertinhez, Ta; Spisni, A; Conti, S.. - In: PLOS ONE. - ISSN 1932-6203. - 7:3(2012), pp. 1-10. [10.1371/journal.pone.0034105]

Peptides of the constant region of antibodies display fungicidal activity

PERICOLINI, Eva;
2012

Abstract

Synthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia furfur, including caspofungin and triazole resistant strains. Alanine-substituted derivatives of fungicidal Fc-peptides, tested to evaluate the critical role of each residue, displayed unaltered, increased or decreased candidacidal activity in vitro. An Fc-peptide, included in all human IgGs, displayed a therapeutic effect against experimental mucosal and systemic candidiasis in mouse models. It is intriguing to hypothesize that some Fc-peptides may influence the antifungal immune response and constitute the basis for devising new antifungal agents.
2012
7
3
1
10
Peptides of the constant region of antibodies display fungicidal activity / Polonelli, L; Ciociola, T; Magliani, W; Zanello, Pp; D'Adda, T; Galati, S; De Bernardis, F; Arancia, S; Gabrielli, E; Pericolini, Eva; Vecchiarelli, A; Arruda, Dc; Pinto, Mr; Travassos, Lr; Pertinhez, Ta; Spisni, A; Conti, S.. - In: PLOS ONE. - ISSN 1932-6203. - 7:3(2012), pp. 1-10. [10.1371/journal.pone.0034105]
Polonelli, L; Ciociola, T; Magliani, W; Zanello, Pp; D'Adda, T; Galati, S; De Bernardis, F; Arancia, S; Gabrielli, E; Pericolini, Eva; Vecchiarelli, A; Arruda, Dc; Pinto, Mr; Travassos, Lr; Pertinhez, Ta; Spisni, A; Conti, S.
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Descrizione: Polonelli L. et al, PLOS ONE 2012
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1120028
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