To evaluate clinical, pathologic and genetic features of desmoplastic melanoma (DM).MATERIALS & METHODS: Analysis of all DM records from 1991 to 2015. RESULTS: The most common location of DMs was the head and neck (69%); median age and follow-up were 60.5 and 7.3 years, respectively. A familial predisposition for DMs and others malignancies was analyzed. Thin Breslow thickness (<4.5 mm) was associated with an intraepidermal component or a previous lentigo maligna, whereas high Breslow thickness (>4.5 mm) was observed in 'pure' DM. CONCLUSION: DM could progress from an early phase, characterized by an intraepidermal component, to late phase, characterized by a dermal nodule. This hypothesis correlates with melanoma genetic and NF1 mutation, which could be an early event in the progression of DM.

Desmoplastic melanoma: a challenge for the oncologist / Manfredini, Marco; Pellacani, Giovanni; Losi, Lorena; Maccaferri, Monia; Tomasi, Aldo; Ponti, Giovanni. - In: FUTURE ONCOLOGY. - ISSN 1479-6694. - STAMPA. - 13:4(2017), pp. 337-345. [10.2217/fon-2016-0334]

Desmoplastic melanoma: a challenge for the oncologist

MANFREDINI, Marco;PELLACANI, Giovanni;LOSI, Lorena;Maccaferri, Monia;TOMASI, Aldo;PONTI, Giovanni
2017

Abstract

To evaluate clinical, pathologic and genetic features of desmoplastic melanoma (DM).MATERIALS & METHODS: Analysis of all DM records from 1991 to 2015. RESULTS: The most common location of DMs was the head and neck (69%); median age and follow-up were 60.5 and 7.3 years, respectively. A familial predisposition for DMs and others malignancies was analyzed. Thin Breslow thickness (<4.5 mm) was associated with an intraepidermal component or a previous lentigo maligna, whereas high Breslow thickness (>4.5 mm) was observed in 'pure' DM. CONCLUSION: DM could progress from an early phase, characterized by an intraepidermal component, to late phase, characterized by a dermal nodule. This hypothesis correlates with melanoma genetic and NF1 mutation, which could be an early event in the progression of DM.
2017
12-ott-2016
13
4
337
345
Desmoplastic melanoma: a challenge for the oncologist / Manfredini, Marco; Pellacani, Giovanni; Losi, Lorena; Maccaferri, Monia; Tomasi, Aldo; Ponti, Giovanni. - In: FUTURE ONCOLOGY. - ISSN 1479-6694. - STAMPA. - 13:4(2017), pp. 337-345. [10.2217/fon-2016-0334]
Manfredini, Marco; Pellacani, Giovanni; Losi, Lorena; Maccaferri, Monia; Tomasi, Aldo; Ponti, Giovanni
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1110683
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