Fusion genes derived from the platelet-derived growth factor receptor beta (PDGFRB) or alpha (PDGFRA) play an important role in the pathogenesis of eosinophilia-associated myeloproliferative neoplasms (Eo-MPN). Here, we would like to report a case of Eo-MPN with normal karyotype and rearrangement of TNIP1-PDGFRB, with unusual clinical presentation, which delayed the diagnosis and initiation of an appropriate therapy. We would also like to provide a review of the so far reported PDGFRB fusion partners in myeloid neoplasms, either myeloproliferative or myelodysplastic, summarizing clinical features and response to imatinib

The importance of cytogenetic and molecular analyses in eosinophilia-associated myeloproliferative neoplasms: an unusual case with normal karyotype and TNIP1- PDGFRB rearrangement and overview of PDGFRB partner genes / Maccaferri, Monica; Pierini, V.; Di Giacomo, D.; Zucchini, Patrizia; Forghieri, Fabio; Bonacorsi, G.; Paolini, Ambra; Quadrelli, Chiara; Giacobbi, F.; Fontana, Francesco; Cappelli, Gianni; Potenza, Leonardo; Marasca, Roberto; Luppi, Mario; Mecucci, C.. - In: LEUKEMIA & LYMPHOMA. - ISSN 1042-8194. - 58:2(2017), pp. 489-493. [10.1080/10428194.2016.1197396]

The importance of cytogenetic and molecular analyses in eosinophilia-associated myeloproliferative neoplasms: an unusual case with normal karyotype and TNIP1- PDGFRB rearrangement and overview of PDGFRB partner genes

MACCAFERRI, Monica
;
ZUCCHINI, Patrizia;FORGHIERI, Fabio;PAOLINI, Ambra;QUADRELLI, Chiara;FONTANA, FRANCESCO;CAPPELLI, Gianni;POTENZA, Leonardo;MARASCA, Roberto;LUPPI, Mario;
2017

Abstract

Fusion genes derived from the platelet-derived growth factor receptor beta (PDGFRB) or alpha (PDGFRA) play an important role in the pathogenesis of eosinophilia-associated myeloproliferative neoplasms (Eo-MPN). Here, we would like to report a case of Eo-MPN with normal karyotype and rearrangement of TNIP1-PDGFRB, with unusual clinical presentation, which delayed the diagnosis and initiation of an appropriate therapy. We would also like to provide a review of the so far reported PDGFRB fusion partners in myeloid neoplasms, either myeloproliferative or myelodysplastic, summarizing clinical features and response to imatinib
2017
24-giu-2016
58
2
489
493
The importance of cytogenetic and molecular analyses in eosinophilia-associated myeloproliferative neoplasms: an unusual case with normal karyotype and TNIP1- PDGFRB rearrangement and overview of PDGFRB partner genes / Maccaferri, Monica; Pierini, V.; Di Giacomo, D.; Zucchini, Patrizia; Forghieri, Fabio; Bonacorsi, G.; Paolini, Ambra; Quadrelli, Chiara; Giacobbi, F.; Fontana, Francesco; Cappelli, Gianni; Potenza, Leonardo; Marasca, Roberto; Luppi, Mario; Mecucci, C.. - In: LEUKEMIA & LYMPHOMA. - ISSN 1042-8194. - 58:2(2017), pp. 489-493. [10.1080/10428194.2016.1197396]
Maccaferri, Monica; Pierini, V.; Di Giacomo, D.; Zucchini, Patrizia; Forghieri, Fabio; Bonacorsi, G.; Paolini, Ambra; Quadrelli, Chiara; Giacobbi, F.; Fontana, Francesco; Cappelli, Gianni; Potenza, Leonardo; Marasca, Roberto; Luppi, Mario; Mecucci, C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1107646
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