The effects of treatment with para-chloro-phenyl-alanine (PCPA) (100 mg/kg i.p. for 4 days) were studied on the hot-plate test and on brain 5-HT binding in phenazone treated rats. Phenazone per se induces analgesia in the hot-plate test and decreases the number of cortical and pontine 5-HT binding sites. A pre-treatment with PCPA prevents both the analgesic effect and the reduction of 5-HT binding sites caused by phenazone. These data suggest that the brain serotonin system may play a role in phenazone-induced antinociception.
THE ROLE OF SEROTONIN BRAIN RECEPTORS IN THE ANALGESIC EFFECT OF PHENAZONE / Pini, Luigi Alberto; Vitale, Giovanni; Sandrini, Maurizio. - In: DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH. - ISSN 0378-6501. - STAMPA. - 19(1):(1993), pp. 13-17.
THE ROLE OF SEROTONIN BRAIN RECEPTORS IN THE ANALGESIC EFFECT OF PHENAZONE
PINI, Luigi Alberto;VITALE, Giovanni;SANDRINI, Maurizio
1993
Abstract
The effects of treatment with para-chloro-phenyl-alanine (PCPA) (100 mg/kg i.p. for 4 days) were studied on the hot-plate test and on brain 5-HT binding in phenazone treated rats. Phenazone per se induces analgesia in the hot-plate test and decreases the number of cortical and pontine 5-HT binding sites. A pre-treatment with PCPA prevents both the analgesic effect and the reduction of 5-HT binding sites caused by phenazone. These data suggest that the brain serotonin system may play a role in phenazone-induced antinociception.
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