The association between the onset of eosinophilic fasciitis and exposure to a drug or a toxin has occasionally been reported. We describe 3 patients who developed eosinophilic fasciitis a few months after they received subcutaneous calcium heparin. In 2 patients, clinical manifestations and eosinophilia improved after interruption of the therapy. Although spontaneous occurrence of eosinophilic fasciitis cannot be excluded in our patients, the temporal relationship with the beginning of subcutaneous heparin therapy raises the possibility that the syndrome might be precipitated by the drug.

Possible association between eosinophilic fasciitis and subcutaneous heparin use / Cantini, F; Salvarani, Carlo; Olivieri, I; Padula, A; Senesi, C; Bellandi, F; Truglia, M. C; Niccoli, L; Palchetti, R.. - In: THE JOURNAL OF RHEUMATOLOGY. - ISSN 0315-162X. - 25:(1998), pp. 383-385.

Possible association between eosinophilic fasciitis and subcutaneous heparin use

SALVARANI, CARLO;
1998

Abstract

The association between the onset of eosinophilic fasciitis and exposure to a drug or a toxin has occasionally been reported. We describe 3 patients who developed eosinophilic fasciitis a few months after they received subcutaneous calcium heparin. In 2 patients, clinical manifestations and eosinophilia improved after interruption of the therapy. Although spontaneous occurrence of eosinophilic fasciitis cannot be excluded in our patients, the temporal relationship with the beginning of subcutaneous heparin therapy raises the possibility that the syndrome might be precipitated by the drug.
1998
25
383
385
Possible association between eosinophilic fasciitis and subcutaneous heparin use / Cantini, F; Salvarani, Carlo; Olivieri, I; Padula, A; Senesi, C; Bellandi, F; Truglia, M. C; Niccoli, L; Palchetti, R.. - In: THE JOURNAL OF RHEUMATOLOGY. - ISSN 0315-162X. - 25:(1998), pp. 383-385.
Cantini, F; Salvarani, Carlo; Olivieri, I; Padula, A; Senesi, C; Bellandi, F; Truglia, M. C; Niccoli, L; Palchetti, R.
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